Мақаланы E-mail арқылы жіберу Role of IGFBP6 Protein in the Regulation of Epithelial-Mesenchymal Transition Genes
- Авторлар: Nikulin S.1,2, Raigorodskaya M.1, Poloznikov A.1, Zakharova G.1, Schumacher U.3, Wicklein D.3, Stürken C.3, Riecken K.3, Fomicheva K.4, Alekseev B.4, Shkurnikov M.4
-
Мекемелер:
- BioClinicum Center
- Moscow Institute of Physics and Technology (MIPT)
- University Medical Center Hamburg-Eppendorf
- P. A. Hertsen Moscow Oncology Research Center, Branch of Branch of National Medical Research Radiology Center of the Ministry of Health of the Russian Federation
- Шығарылым: Том 164, № 5 (2018)
- Беттер: 650-654
- Бөлім: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/239813
- DOI: https://doi.org/10.1007/s10517-018-4051-8
- ID: 239813
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
Protein IGFBP6 plays an important role in the pathogenesis of many malignant tumors, including breast cancer. The relationship between IGFBP6 protein and the expression of genes associated with the epithelial-mesenchymal transition is studied. Gene IGFBP6 knockdown does not trigger the epithelial-mesenchymal transition in MDA-MB-231 cells, but modifies significantly the expression of many genes involved in this process. A decrease of IGFBP6 expression can involve a decrease in the expression of N-cadherin and transcription factor Slug.
Авторлар туралы
S. Nikulin
BioClinicum Center; Moscow Institute of Physics and Technology (MIPT)
Email: byalekseev@mail.ru
Ресей, Moscow; Moscow
M. Raigorodskaya
BioClinicum Center
Email: byalekseev@mail.ru
Ресей, Moscow
A. Poloznikov
BioClinicum Center
Email: byalekseev@mail.ru
Ресей, Moscow
G. Zakharova
BioClinicum Center
Email: byalekseev@mail.ru
Ресей, Moscow
U. Schumacher
University Medical Center Hamburg-Eppendorf
Email: byalekseev@mail.ru
Германия, Hamburg
D. Wicklein
University Medical Center Hamburg-Eppendorf
Email: byalekseev@mail.ru
Германия, Hamburg
C. Stürken
University Medical Center Hamburg-Eppendorf
Email: byalekseev@mail.ru
Германия, Hamburg
K. Riecken
University Medical Center Hamburg-Eppendorf
Email: byalekseev@mail.ru
Германия, Hamburg
K. Fomicheva
P. A. Hertsen Moscow Oncology Research Center, Branch of Branch of National Medical Research Radiology Center of the Ministry of Health of the Russian Federation
Email: byalekseev@mail.ru
Ресей, Moscow
B. Alekseev
P. A. Hertsen Moscow Oncology Research Center, Branch of Branch of National Medical Research Radiology Center of the Ministry of Health of the Russian Federation
Хат алмасуға жауапты Автор.
Email: byalekseev@mail.ru
Ресей, Moscow
M. Shkurnikov
P. A. Hertsen Moscow Oncology Research Center, Branch of Branch of National Medical Research Radiology Center of the Ministry of Health of the Russian Federation
Email: byalekseev@mail.ru
Ресей, Moscow
