电邮这篇文章 Role of IGFBP6 Protein in the Regulation of Epithelial-Mesenchymal Transition Genes
- 作者: Nikulin S.1,2, Raigorodskaya M.1, Poloznikov A.1, Zakharova G.1, Schumacher U.3, Wicklein D.3, Stürken C.3, Riecken K.3, Fomicheva K.4, Alekseev B.4, Shkurnikov M.4
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隶属关系:
- BioClinicum Center
- Moscow Institute of Physics and Technology (MIPT)
- University Medical Center Hamburg-Eppendorf
- P. A. Hertsen Moscow Oncology Research Center, Branch of Branch of National Medical Research Radiology Center of the Ministry of Health of the Russian Federation
- 期: 卷 164, 编号 5 (2018)
- 页面: 650-654
- 栏目: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/239813
- DOI: https://doi.org/10.1007/s10517-018-4051-8
- ID: 239813
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详细
Protein IGFBP6 plays an important role in the pathogenesis of many malignant tumors, including breast cancer. The relationship between IGFBP6 protein and the expression of genes associated with the epithelial-mesenchymal transition is studied. Gene IGFBP6 knockdown does not trigger the epithelial-mesenchymal transition in MDA-MB-231 cells, but modifies significantly the expression of many genes involved in this process. A decrease of IGFBP6 expression can involve a decrease in the expression of N-cadherin and transcription factor Slug.
作者简介
S. Nikulin
BioClinicum Center; Moscow Institute of Physics and Technology (MIPT)
Email: byalekseev@mail.ru
俄罗斯联邦, Moscow; Moscow
M. Raigorodskaya
BioClinicum Center
Email: byalekseev@mail.ru
俄罗斯联邦, Moscow
A. Poloznikov
BioClinicum Center
Email: byalekseev@mail.ru
俄罗斯联邦, Moscow
G. Zakharova
BioClinicum Center
Email: byalekseev@mail.ru
俄罗斯联邦, Moscow
U. Schumacher
University Medical Center Hamburg-Eppendorf
Email: byalekseev@mail.ru
德国, Hamburg
D. Wicklein
University Medical Center Hamburg-Eppendorf
Email: byalekseev@mail.ru
德国, Hamburg
C. Stürken
University Medical Center Hamburg-Eppendorf
Email: byalekseev@mail.ru
德国, Hamburg
K. Riecken
University Medical Center Hamburg-Eppendorf
Email: byalekseev@mail.ru
德国, Hamburg
K. Fomicheva
P. A. Hertsen Moscow Oncology Research Center, Branch of Branch of National Medical Research Radiology Center of the Ministry of Health of the Russian Federation
Email: byalekseev@mail.ru
俄罗斯联邦, Moscow
B. Alekseev
P. A. Hertsen Moscow Oncology Research Center, Branch of Branch of National Medical Research Radiology Center of the Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: byalekseev@mail.ru
俄罗斯联邦, Moscow
M. Shkurnikov
P. A. Hertsen Moscow Oncology Research Center, Branch of Branch of National Medical Research Radiology Center of the Ministry of Health of the Russian Federation
Email: byalekseev@mail.ru
俄罗斯联邦, Moscow
