Effect of GRP119 Receptor Agonist, Compound MBX-2982, on Activity of Human Glucokinase
- Authors: Spasov A.A.1, Kosolapov V.A.1, Babkov D.A.1, Maika O.Y.1
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Affiliations:
- Volgograd State Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 163, No 5 (2017)
- Pages: 695-698
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239198
- DOI: https://doi.org/10.1007/s10517-017-3881-0
- ID: 239198
Cite item
Abstract
Validation of the method for studies of glucokinase activators by the spectrophotometric method in an in vitro test system is carried out. The advantage of NAD coenzyme vs. thio-NAD is proven. Manifest activation of glucokinase by MBX-2982 compound (GPR119 agonist) in a wide range of concentrations is demonstrated experimentally.
About the authors
A. A. Spasov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: aspasov@mail.ru
Russian Federation, Volgograd
V. A. Kosolapov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: aspasov@mail.ru
Russian Federation, Volgograd
D. A. Babkov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: aspasov@mail.ru
Russian Federation, Volgograd
O. Yu. Maika
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: aspasov@mail.ru
Russian Federation, Volgograd