Email this article Effect of Electroconvulsive Therapy on Cognitive Functions of Rats with Depression-Like Disorders Induced by Ultrasound Exposure
- Authors: Ushakova V.M.1, Zubkov E.A.2, Morozova A.Y.2, Gorlova A.V.1, Pavlov D.A.1, Inozemtsev A.N.1, Chekhonin V.P.2,3
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Affiliations:
- Department of Higher Nervous Function, M. V. Lomonosov Moscow State University
- Department of Fundamental and Applied Neurobiology, V. P. Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Ministry of Health of the Russian Federation
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 163, No 5 (2017)
- Pages: 599-601
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239115
- DOI: https://doi.org/10.1007/s10517-017-3857-0
- ID: 239115
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Abstract
We studied the effect of electroconvulsive therapy on cognitive functions in rats with depression-like disorder caused by exposure to ultrasound of varying frequency (20-45 kHz). Object recognition and Morris water-maze tests revealed no negative effects of the therapy on memory. Moreover, positive effect of therapy was demonstrated that manifested in amelioration of memory disturbances in depression-like disorders in these behavioral tests. The results of this study do not support the idea about side effects of electroconvulsive therapy, in particular, development of transient amnesia, and are a prerequisite for a more thorough study of internal mechanisms of the effect of the therapy on cognitive sphere.
About the authors
V. M. Ushakova
Department of Higher Nervous Function, M. V. Lomonosov Moscow State University
Author for correspondence.
Email: scobelevavm@gmail.com
Russian Federation, Moscow
E. A. Zubkov
Department of Fundamental and Applied Neurobiology, V. P. Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Ministry of Health of the Russian Federation
Email: scobelevavm@gmail.com
Russian Federation, Moscow
A. Y. Morozova
Department of Fundamental and Applied Neurobiology, V. P. Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Ministry of Health of the Russian Federation
Email: scobelevavm@gmail.com
Russian Federation, Moscow
A. V. Gorlova
Department of Higher Nervous Function, M. V. Lomonosov Moscow State University
Email: scobelevavm@gmail.com
Russian Federation, Moscow
D. A. Pavlov
Department of Higher Nervous Function, M. V. Lomonosov Moscow State University
Email: scobelevavm@gmail.com
Russian Federation, Moscow
A. N. Inozemtsev
Department of Higher Nervous Function, M. V. Lomonosov Moscow State University
Email: scobelevavm@gmail.com
Russian Federation, Moscow
V. P. Chekhonin
Department of Fundamental and Applied Neurobiology, V. P. Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Ministry of Health of the Russian Federation; N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: scobelevavm@gmail.com
Russian Federation, Moscow; Moscow
