Email this article Reconstruction of Ligament and Tendon Defects Using Cell Technologies
- Authors: Chailakhyan R.K.1, Shekhter A.B.2, Ivannikov S.V.2, Tel’pukhov V.I.2, Suslin D.S.2, Gerasimov Y.V.1, Tonenkov A.M.2, Grosheva A.G.1, Panyushkin P.V.2, Moskvina I.L.1, Vorob’eva N.N.3, Bagratashvili V.N.3
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Affiliations:
- N. F. Gamaleya Research Centre of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
- I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
- Institute of Photonics Technologies, Russian Academy of Sciences, Federal Research Center “Crystallography and Photonics”, Russian Academy of Sciences
- Issue: Vol 162, No 4 (2017)
- Pages: 563-568
- Section: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/238378
- DOI: https://doi.org/10.1007/s10517-017-3660-y
- ID: 238378
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Abstract
We studied the possibility of restoring the integrity of the Achilles tendon in rabbits using autologous multipotent stromal cells. Collagen or gelatin sponges populated with cells were placed in a resorbable Vicryl mesh tube and this tissue-engineered construct was introduced into a defect of the middle part of the Achilles tendon. In 4 months, histological analysis showed complete regeneration of the tendon with the formation of parallel collagen fibers, spindle-shaped tenocytes, and newly formed vessels.
About the authors
R. K. Chailakhyan
N. F. Gamaleya Research Centre of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: rubenchail@yandex.ru
Russian Federation, Moscow
A. B. Shekhter
I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
Email: rubenchail@yandex.ru
Russian Federation, Moscow
S. V. Ivannikov
I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
Email: rubenchail@yandex.ru
Russian Federation, Moscow
V. I. Tel’pukhov
I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
Email: rubenchail@yandex.ru
Russian Federation, Moscow
D. S. Suslin
I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
Email: rubenchail@yandex.ru
Russian Federation, Moscow
Yu. V. Gerasimov
N. F. Gamaleya Research Centre of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: rubenchail@yandex.ru
Russian Federation, Moscow
A. M. Tonenkov
I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
Email: rubenchail@yandex.ru
Russian Federation, Moscow
A. G. Grosheva
N. F. Gamaleya Research Centre of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: rubenchail@yandex.ru
Russian Federation, Moscow
P. V. Panyushkin
I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
Email: rubenchail@yandex.ru
Russian Federation, Moscow
I. L. Moskvina
N. F. Gamaleya Research Centre of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: rubenchail@yandex.ru
Russian Federation, Moscow
N. N. Vorob’eva
Institute of Photonics Technologies, Russian Academy of Sciences, Federal Research Center “Crystallography and Photonics”, Russian Academy of Sciences
Email: rubenchail@yandex.ru
Russian Federation, Moscow
V. N. Bagratashvili
Institute of Photonics Technologies, Russian Academy of Sciences, Federal Research Center “Crystallography and Photonics”, Russian Academy of Sciences
Email: rubenchail@yandex.ru
Russian Federation, Moscow
