Reconstruction of Ligament and Tendon Defects Using Cell Technologies


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We studied the possibility of restoring the integrity of the Achilles tendon in rabbits using autologous multipotent stromal cells. Collagen or gelatin sponges populated with cells were placed in a resorbable Vicryl mesh tube and this tissue-engineered construct was introduced into a defect of the middle part of the Achilles tendon. In 4 months, histological analysis showed complete regeneration of the tendon with the formation of parallel collagen fibers, spindle-shaped tenocytes, and newly formed vessels.

作者简介

R. Chailakhyan

N. F. Gamaleya Research Centre of Epidemiology and Microbiology, Ministry of Health of the Russian Federation

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Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow

A. Shekhter

I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation

Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow

S. Ivannikov

I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation

Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow

V. Tel’pukhov

I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation

Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow

D. Suslin

I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation

Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow

Yu. Gerasimov

N. F. Gamaleya Research Centre of Epidemiology and Microbiology, Ministry of Health of the Russian Federation

Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow

A. Tonenkov

I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation

Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow

A. Grosheva

N. F. Gamaleya Research Centre of Epidemiology and Microbiology, Ministry of Health of the Russian Federation

Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow

P. Panyushkin

I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation

Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow

I. Moskvina

N. F. Gamaleya Research Centre of Epidemiology and Microbiology, Ministry of Health of the Russian Federation

Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow

N. Vorob’eva

Institute of Photonics Technologies, Russian Academy of Sciences, Federal Research Center “Crystallography and Photonics”, Russian Academy of Sciences

Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow

V. Bagratashvili

Institute of Photonics Technologies, Russian Academy of Sciences, Federal Research Center “Crystallography and Photonics”, Russian Academy of Sciences

Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow

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