Email this article Immunogenesis in White Mice Infected with Yersinia pestis with Different Plasmid Composition
- Authors: Balakhonov S.V.1, Vityazeva S.A.1, Dubrovina V.I.1, Starovoitova T.P.1, Mukhturgin G.B.1, Ivanova T.A.1, Korytov K.M.1, Kolesnikov S.I.2
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Affiliations:
- Irkutsk Antiplague Research Institute of Siberia and Far East of Federal Service on Supervision in the Sphere of Consumers’ Rights Protection and Human Welfare
- Research Center of Family Health Problems and Human Reproduction
- Issue: Vol 162, No 4 (2017)
- Pages: 470-473
- Section: Microbiology and Immunology
- URL: https://journals.rcsi.science/0007-4888/article/view/238307
- DOI: https://doi.org/10.1007/s10517-017-3642-0
- ID: 238307
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Abstract
Morphological changes in the immunocompetent organs of white mice with experimental plague infection manifested in activation of the immune response of different degree and pathological process of different severity that depended on the plasmid composition of Y. pestis. Widening of the T-dependent zones in the immune organs of white mice infected with isogenic strains of Y. pestis with different plasmid composition attests to activation of cellular immunity. Our findings allow considering Y. pestis subsp. altaica I-2948/3, Y. pestis subsp. pestis I-3479 and Y. pestis subsp. pestis I-3480 as promising candidates for vaccine strains.
About the authors
S. V. Balakhonov
Irkutsk Antiplague Research Institute of Siberia and Far East of Federal Service on Supervision in the Sphere of Consumers’ Rights Protection and Human Welfare
Email: dubrovina-valya@mail.ru
Russian Federation, Irkutsk
S. A. Vityazeva
Irkutsk Antiplague Research Institute of Siberia and Far East of Federal Service on Supervision in the Sphere of Consumers’ Rights Protection and Human Welfare
Email: dubrovina-valya@mail.ru
Russian Federation, Irkutsk
V. I. Dubrovina
Irkutsk Antiplague Research Institute of Siberia and Far East of Federal Service on Supervision in the Sphere of Consumers’ Rights Protection and Human Welfare
Author for correspondence.
Email: dubrovina-valya@mail.ru
Russian Federation, Irkutsk
T. P. Starovoitova
Irkutsk Antiplague Research Institute of Siberia and Far East of Federal Service on Supervision in the Sphere of Consumers’ Rights Protection and Human Welfare
Email: dubrovina-valya@mail.ru
Russian Federation, Irkutsk
G. B. Mukhturgin
Irkutsk Antiplague Research Institute of Siberia and Far East of Federal Service on Supervision in the Sphere of Consumers’ Rights Protection and Human Welfare
Email: dubrovina-valya@mail.ru
Russian Federation, Irkutsk
T. A. Ivanova
Irkutsk Antiplague Research Institute of Siberia and Far East of Federal Service on Supervision in the Sphere of Consumers’ Rights Protection and Human Welfare
Email: dubrovina-valya@mail.ru
Russian Federation, Irkutsk
K. M. Korytov
Irkutsk Antiplague Research Institute of Siberia and Far East of Federal Service on Supervision in the Sphere of Consumers’ Rights Protection and Human Welfare
Email: dubrovina-valya@mail.ru
Russian Federation, Irkutsk
S. I. Kolesnikov
Research Center of Family Health Problems and Human Reproduction
Email: dubrovina-valya@mail.ru
Russian Federation, Irkutsk
