Immunogenesis in White Mice Infected with Yersinia pestis with Different Plasmid Composition


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Morphological changes in the immunocompetent organs of white mice with experimental plague infection manifested in activation of the immune response of different degree and pathological process of different severity that depended on the plasmid composition of Y. pestis. Widening of the T-dependent zones in the immune organs of white mice infected with isogenic strains of Y. pestis with different plasmid composition attests to activation of cellular immunity. Our findings allow considering Y. pestis subsp. altaica I-2948/3, Y. pestis subsp. pestis I-3479 and Y. pestis subsp. pestis I-3480 as promising candidates for vaccine strains.

作者简介

S. Balakhonov

Irkutsk Antiplague Research Institute of Siberia and Far East of Federal Service on Supervision in the Sphere of Consumers’ Rights Protection and Human Welfare

Email: dubrovina-valya@mail.ru
俄罗斯联邦, Irkutsk

S. Vityazeva

Irkutsk Antiplague Research Institute of Siberia and Far East of Federal Service on Supervision in the Sphere of Consumers’ Rights Protection and Human Welfare

Email: dubrovina-valya@mail.ru
俄罗斯联邦, Irkutsk

V. Dubrovina

Irkutsk Antiplague Research Institute of Siberia and Far East of Federal Service on Supervision in the Sphere of Consumers’ Rights Protection and Human Welfare

编辑信件的主要联系方式.
Email: dubrovina-valya@mail.ru
俄罗斯联邦, Irkutsk

T. Starovoitova

Irkutsk Antiplague Research Institute of Siberia and Far East of Federal Service on Supervision in the Sphere of Consumers’ Rights Protection and Human Welfare

Email: dubrovina-valya@mail.ru
俄罗斯联邦, Irkutsk

G. Mukhturgin

Irkutsk Antiplague Research Institute of Siberia and Far East of Federal Service on Supervision in the Sphere of Consumers’ Rights Protection and Human Welfare

Email: dubrovina-valya@mail.ru
俄罗斯联邦, Irkutsk

T. Ivanova

Irkutsk Antiplague Research Institute of Siberia and Far East of Federal Service on Supervision in the Sphere of Consumers’ Rights Protection and Human Welfare

Email: dubrovina-valya@mail.ru
俄罗斯联邦, Irkutsk

K. Korytov

Irkutsk Antiplague Research Institute of Siberia and Far East of Federal Service on Supervision in the Sphere of Consumers’ Rights Protection and Human Welfare

Email: dubrovina-valya@mail.ru
俄罗斯联邦, Irkutsk

S. Kolesnikov

Research Center of Family Health Problems and Human Reproduction

Email: dubrovina-valya@mail.ru
俄罗斯联邦, Irkutsk


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