Effects of Anti-CD206 Antibodies on Macrophage Functions in Male CBF1 Mice with Lipidemia

A. P. Lykov; T. A. Korolenko; L. V. Sakhno; O. V. Poveshchenko; N. A. Bondarenko; M. A. Surovtseva; N. V. Goncharova

doi:10.1007/s10517-016-3584-y

Effects of Anti-CD206 Antibodies on Macrophage Functions in Male CBF1 Mice with Lipidemia

Authors: Lykov A.P.¹, Korolenko T.A.², Sakhno L.V.³, Poveshchenko O.V.¹, Bondarenko N.A.¹, Surovtseva M.A.¹, Goncharova N.V.²
Affiliations:
1. Research Institute of Clinical and Experimental Lymphology
2. Research Institute of Physiology and Fundamental Medicine
3. Institute of Fundamental and Clinical Immunology
Issue: Vol 162, No 2 (2016)
Pages: 237-239
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/238073
DOI: https://doi.org/10.1007/s10517-016-3584-y
ID: 238073

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Abstract

The effects of anti-CD208 antibodies (mannose receptor) on functional characteristics of peritoneal macrophages were studied in intact mice and mice with lipidemia induced by poloxamer-407. Lipidemia was associated with suppression of phagocytosis and increase in spontaneous proliferative potential and NO production by macrophages. Anti-CD206 antibodies suppressed NO production by macrophages in mice with lipidemia.