Email this article Pro-Cognitive Effects of Non-Peptide Analogues of Soluble Amyloid Peptide Precursor Fragment sAPP
- Authors: Tiunova A.A.1, Komissarova N.V.1, Nenaidenko V.G.2, Makhmutova A.A.3, Beznosko B.K.3, Bachurin S.O.3, Anokhin K.V.1,4
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Affiliations:
- P. K. Anokhin Research Institute of Normal Physiology, M. V. Lomonosov Moscow State University
- Chemical Faculty, M. V. Lomonosov Moscow State University
- Institute of Physiologically Active Substances, Russian Academy of Sciences
- NBICS Center, National Research Center Kurchatov Institute
- Issue: Vol 161, No 4 (2016)
- Pages: 447-450
- Section: Physiology
- URL: https://journals.rcsi.science/0007-4888/article/view/237508
- DOI: https://doi.org/10.1007/s10517-016-3435-x
- ID: 237508
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Abstract
We studied pro-cognitive effect of two heterocyclic low-molecular-weight compounds that serve as non-peptide analogues of soluble fragment of amyloid peptide precursor (sAPP). Intracerebroventricular and systemic administration of peptide mimetics P2 and P5 improved weak memory on the model of passive avoidance in chicks and in the object location task in mice. Both compounds were effective if administered close to the moment of training or 4 h after it. The time windows and dose range for the pro-cognitive effects of the mimetics were similar to those observed in previous studies with sAPP peptide fragments.
About the authors
A. A. Tiunova
P. K. Anokhin Research Institute of Normal Physiology, M. V. Lomonosov Moscow State University
Author for correspondence.
Email: aat699@yahoo.com
Russian Federation, Moscow
N. V. Komissarova
P. K. Anokhin Research Institute of Normal Physiology, M. V. Lomonosov Moscow State University
Email: aat699@yahoo.com
Russian Federation, Moscow
V. G. Nenaidenko
Chemical Faculty, M. V. Lomonosov Moscow State University
Email: aat699@yahoo.com
Russian Federation, Moscow
A. A. Makhmutova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: aat699@yahoo.com
Russian Federation, Chernogolovka, Moscow Region
B. K. Beznosko
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: aat699@yahoo.com
Russian Federation, Chernogolovka, Moscow Region
S. O. Bachurin
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: aat699@yahoo.com
Russian Federation, Chernogolovka, Moscow Region
K. V. Anokhin
P. K. Anokhin Research Institute of Normal Physiology, M. V. Lomonosov Moscow State University; NBICS Center, National Research Center Kurchatov Institute
Email: aat699@yahoo.com
Russian Federation, Moscow; Moscow
