Enviar artigo por via de e-mail Pro-Cognitive Effects of Non-Peptide Analogues of Soluble Amyloid Peptide Precursor Fragment sAPP
- Autores: Tiunova A.1, Komissarova N.1, Nenaidenko V.2, Makhmutova A.3, Beznosko B.3, Bachurin S.3, Anokhin K.1,4
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Afiliações:
- P. K. Anokhin Research Institute of Normal Physiology, M. V. Lomonosov Moscow State University
- Chemical Faculty, M. V. Lomonosov Moscow State University
- Institute of Physiologically Active Substances, Russian Academy of Sciences
- NBICS Center, National Research Center Kurchatov Institute
- Edição: Volume 161, Nº 4 (2016)
- Páginas: 447-450
- Seção: Physiology
- URL: https://journals.rcsi.science/0007-4888/article/view/237508
- DOI: https://doi.org/10.1007/s10517-016-3435-x
- ID: 237508
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Resumo
We studied pro-cognitive effect of two heterocyclic low-molecular-weight compounds that serve as non-peptide analogues of soluble fragment of amyloid peptide precursor (sAPP). Intracerebroventricular and systemic administration of peptide mimetics P2 and P5 improved weak memory on the model of passive avoidance in chicks and in the object location task in mice. Both compounds were effective if administered close to the moment of training or 4 h after it. The time windows and dose range for the pro-cognitive effects of the mimetics were similar to those observed in previous studies with sAPP peptide fragments.
Sobre autores
A. Tiunova
P. K. Anokhin Research Institute of Normal Physiology, M. V. Lomonosov Moscow State University
Autor responsável pela correspondência
Email: aat699@yahoo.com
Rússia, Moscow
N. Komissarova
P. K. Anokhin Research Institute of Normal Physiology, M. V. Lomonosov Moscow State University
Email: aat699@yahoo.com
Rússia, Moscow
V. Nenaidenko
Chemical Faculty, M. V. Lomonosov Moscow State University
Email: aat699@yahoo.com
Rússia, Moscow
A. Makhmutova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: aat699@yahoo.com
Rússia, Chernogolovka, Moscow Region
B. Beznosko
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: aat699@yahoo.com
Rússia, Chernogolovka, Moscow Region
S. Bachurin
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: aat699@yahoo.com
Rússia, Chernogolovka, Moscow Region
K. Anokhin
P. K. Anokhin Research Institute of Normal Physiology, M. V. Lomonosov Moscow State University; NBICS Center, National Research Center Kurchatov Institute
Email: aat699@yahoo.com
Rússia, Moscow; Moscow
