Pro-Cognitive Effects of Non-Peptide Analogues of Soluble Amyloid Peptide Precursor Fragment sAPP
- 作者: Tiunova A.1, Komissarova N.1, Nenaidenko V.2, Makhmutova A.3, Beznosko B.3, Bachurin S.3, Anokhin K.1,4
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隶属关系:
- P. K. Anokhin Research Institute of Normal Physiology, M. V. Lomonosov Moscow State University
- Chemical Faculty, M. V. Lomonosov Moscow State University
- Institute of Physiologically Active Substances, Russian Academy of Sciences
- NBICS Center, National Research Center Kurchatov Institute
- 期: 卷 161, 编号 4 (2016)
- 页面: 447-450
- 栏目: Physiology
- URL: https://journals.rcsi.science/0007-4888/article/view/237508
- DOI: https://doi.org/10.1007/s10517-016-3435-x
- ID: 237508
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详细
We studied pro-cognitive effect of two heterocyclic low-molecular-weight compounds that serve as non-peptide analogues of soluble fragment of amyloid peptide precursor (sAPP). Intracerebroventricular and systemic administration of peptide mimetics P2 and P5 improved weak memory on the model of passive avoidance in chicks and in the object location task in mice. Both compounds were effective if administered close to the moment of training or 4 h after it. The time windows and dose range for the pro-cognitive effects of the mimetics were similar to those observed in previous studies with sAPP peptide fragments.
作者简介
A. Tiunova
P. K. Anokhin Research Institute of Normal Physiology, M. V. Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: aat699@yahoo.com
俄罗斯联邦, Moscow
N. Komissarova
P. K. Anokhin Research Institute of Normal Physiology, M. V. Lomonosov Moscow State University
Email: aat699@yahoo.com
俄罗斯联邦, Moscow
V. Nenaidenko
Chemical Faculty, M. V. Lomonosov Moscow State University
Email: aat699@yahoo.com
俄罗斯联邦, Moscow
A. Makhmutova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: aat699@yahoo.com
俄罗斯联邦, Chernogolovka, Moscow Region
B. Beznosko
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: aat699@yahoo.com
俄罗斯联邦, Chernogolovka, Moscow Region
S. Bachurin
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: aat699@yahoo.com
俄罗斯联邦, Chernogolovka, Moscow Region
K. Anokhin
P. K. Anokhin Research Institute of Normal Physiology, M. V. Lomonosov Moscow State University; NBICS Center, National Research Center Kurchatov Institute
Email: aat699@yahoo.com
俄罗斯联邦, Moscow; Moscow