Email this article Effect of Acute Emotional Stress on Proteomic Profile of Selected Brain Areas and Lysosomal Proteolysis in Rats with Different Behavioral Activity
- Authors: Sharanova N.E.1, Kirbaeva N.V.1, Toropygin I.Y.2, Khryapova E.V.2, Koplik E.V.3, Soto C.K.1, Pertsov S.S.3, Vasiliev A.V.1
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Affiliations:
- Institute of Nutrition of Russian Academy of Medical Sciences
- Human Proteome, Center of Common Use, V. N. Orekhovich Research Institute of Biomedical Chemistry
- P. K. Anokhin Research Institute of Normal Physiology
- Issue: Vol 161, No 3 (2016)
- Pages: 355-358
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237414
- DOI: https://doi.org/10.1007/s10517-016-3413-3
- ID: 237414
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Abstract
We compared proteome profiles of selected brain areas (cortex, amygdala, hippocampus, and reticular formation) and measured cathepsins B and D activity in liver lysosomal fraction in rats with different behavioral activity under conditions of emotional stress. In passive rats, the expression of some proteins in various brain regions was changed and baseline cathepsin B activity was higher than in active animals. Taken together, the results attest to differences in the adaptive response formation in rats, depending on behavioral features.
About the authors
N. E. Sharanova
Institute of Nutrition of Russian Academy of Medical Sciences
Author for correspondence.
Email: sharanova@ion.ru
Russian Federation, Moscow
N. V. Kirbaeva
Institute of Nutrition of Russian Academy of Medical Sciences
Email: sharanova@ion.ru
Russian Federation, Moscow
I. Yu. Toropygin
Human Proteome, Center of Common Use, V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: sharanova@ion.ru
Russian Federation, Moscow
E. V. Khryapova
Human Proteome, Center of Common Use, V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: sharanova@ion.ru
Russian Federation, Moscow
E. V. Koplik
P. K. Anokhin Research Institute of Normal Physiology
Email: sharanova@ion.ru
Russian Federation, Moscow
C. Kh. Soto
Institute of Nutrition of Russian Academy of Medical Sciences
Email: sharanova@ion.ru
Russian Federation, Moscow
S. S. Pertsov
P. K. Anokhin Research Institute of Normal Physiology
Email: sharanova@ion.ru
Russian Federation, Moscow
A. V. Vasiliev
Institute of Nutrition of Russian Academy of Medical Sciences
Email: sharanova@ion.ru
Russian Federation, Moscow
