Effect of Acute Emotional Stress on Proteomic Profile of Selected Brain Areas and Lysosomal Proteolysis in Rats with Different Behavioral Activity
- Авторы: Sharanova N.1, Kirbaeva N.1, Toropygin I.2, Khryapova E.2, Koplik E.3, Soto C.1, Pertsov S.3, Vasiliev A.1
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Учреждения:
- Institute of Nutrition of Russian Academy of Medical Sciences
- Human Proteome, Center of Common Use, V. N. Orekhovich Research Institute of Biomedical Chemistry
- P. K. Anokhin Research Institute of Normal Physiology
- Выпуск: Том 161, № 3 (2016)
- Страницы: 355-358
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237414
- DOI: https://doi.org/10.1007/s10517-016-3413-3
- ID: 237414
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Аннотация
We compared proteome profiles of selected brain areas (cortex, amygdala, hippocampus, and reticular formation) and measured cathepsins B and D activity in liver lysosomal fraction in rats with different behavioral activity under conditions of emotional stress. In passive rats, the expression of some proteins in various brain regions was changed and baseline cathepsin B activity was higher than in active animals. Taken together, the results attest to differences in the adaptive response formation in rats, depending on behavioral features.
Об авторах
N. Sharanova
Institute of Nutrition of Russian Academy of Medical Sciences
Автор, ответственный за переписку.
Email: sharanova@ion.ru
Россия, Moscow
N. Kirbaeva
Institute of Nutrition of Russian Academy of Medical Sciences
Email: sharanova@ion.ru
Россия, Moscow
I. Toropygin
Human Proteome, Center of Common Use, V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: sharanova@ion.ru
Россия, Moscow
E. Khryapova
Human Proteome, Center of Common Use, V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: sharanova@ion.ru
Россия, Moscow
E. Koplik
P. K. Anokhin Research Institute of Normal Physiology
Email: sharanova@ion.ru
Россия, Moscow
C. Soto
Institute of Nutrition of Russian Academy of Medical Sciences
Email: sharanova@ion.ru
Россия, Moscow
S. Pertsov
P. K. Anokhin Research Institute of Normal Physiology
Email: sharanova@ion.ru
Россия, Moscow
A. Vasiliev
Institute of Nutrition of Russian Academy of Medical Sciences
Email: sharanova@ion.ru
Россия, Moscow