Email this article Silicon Nanoparticles as Amplifiers of the Ultrasonic Effect in Sonodynamic Therapy
- Authors: Osminkina L.A.1, Kudryavtsev A.A.2, Zinovyev S.V.3, Sviridov A.P.1, Kargina Y.V.1, Tamarov K.P.1, Nikiforov V.N.1, Ivanov A.V.3, Vasilyev A.N.1,4, Timoshenko V.Y.1
-
Affiliations:
- Physical Faculty, M. V. Lomonosov Moscow State University
- Institute of Theoretical and Experimental Biophysics, the Russian Academy of Sciences
- N. N. Blokhin Russian Cancer Research Center
- Ural Federal University
- Issue: Vol 161, No 2 (2016)
- Pages: 296-299
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237347
- DOI: https://doi.org/10.1007/s10517-016-3399-x
- ID: 237347
Cite item
Open Access
Access granted
Subscription Access
Abstract
The possibility of using mesoporous silicon nanoparticles as amplifiers (sensitizers) of therapeutic ultrasonic exposure were studied experimentally in vitro and in vivo. The combination of nanoparticles and ultrasound led to a significant inhibition of Hep-2 cancer cell proliferation and Lewis lung carcinoma growth in mice. These results indicated good prospects of using silicon nanoparticles as sensitizers for sonodynamic therapy of tumors.
About the authors
L. A. Osminkina
Physical Faculty, M. V. Lomonosov Moscow State University
Author for correspondence.
Email: osminkina@mig.phys.msu.ru
Russian Federation, Moscow
A. A. Kudryavtsev
Institute of Theoretical and Experimental Biophysics, the Russian Academy of Sciences
Email: osminkina@mig.phys.msu.ru
Russian Federation, Pushchino, Moscow Region
S. V. Zinovyev
N. N. Blokhin Russian Cancer Research Center
Email: osminkina@mig.phys.msu.ru
Russian Federation, Moscow
A. P. Sviridov
Physical Faculty, M. V. Lomonosov Moscow State University
Email: osminkina@mig.phys.msu.ru
Russian Federation, Moscow
Yu. V. Kargina
Physical Faculty, M. V. Lomonosov Moscow State University
Email: osminkina@mig.phys.msu.ru
Russian Federation, Moscow
K. P. Tamarov
Physical Faculty, M. V. Lomonosov Moscow State University
Email: osminkina@mig.phys.msu.ru
Russian Federation, Moscow
V. N. Nikiforov
Physical Faculty, M. V. Lomonosov Moscow State University
Email: osminkina@mig.phys.msu.ru
Russian Federation, Moscow
A. V. Ivanov
N. N. Blokhin Russian Cancer Research Center
Email: osminkina@mig.phys.msu.ru
Russian Federation, Moscow
A. N. Vasilyev
Physical Faculty, M. V. Lomonosov Moscow State University; Ural Federal University
Email: osminkina@mig.phys.msu.ru
Russian Federation, Moscow; Ekaterinburg
V. Yu. Timoshenko
Physical Faculty, M. V. Lomonosov Moscow State University
Email: osminkina@mig.phys.msu.ru
Russian Federation, Moscow
