Silicon Nanoparticles as Amplifiers of the Ultrasonic Effect in Sonodynamic Therapy

L. A. Osminkina; A. A. Kudryavtsev; S. V. Zinovyev; A. P. Sviridov; Yu. V. Kargina; K. P. Tamarov; V. N. Nikiforov; A. V. Ivanov; A. N. Vasilyev; V. Yu. Timoshenko

doi:10.1007/s10517-016-3399-x

Silicon Nanoparticles as Amplifiers of the Ultrasonic Effect in Sonodynamic Therapy

作者: Osminkina L.¹, Kudryavtsev A.², Zinovyev S.³, Sviridov A.¹, Kargina Y.¹, Tamarov K.¹, Nikiforov V.¹, Ivanov A.³, Vasilyev A.¹^,4, Timoshenko V.¹
隶属关系:
1. Physical Faculty, M. V. Lomonosov Moscow State University
2. Institute of Theoretical and Experimental Biophysics, the Russian Academy of Sciences
3. N. N. Blokhin Russian Cancer Research Center
4. Ural Federal University
期: 卷 161, 编号 2 (2016)
页面: 296-299
栏目: Article
URL: https://journals.rcsi.science/0007-4888/article/view/237347
DOI: https://doi.org/10.1007/s10517-016-3399-x
ID: 237347

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The possibility of using mesoporous silicon nanoparticles as amplifiers (sensitizers) of therapeutic ultrasonic exposure were studied experimentally in vitro and in vivo. The combination of nanoparticles and ultrasound led to a significant inhibition of Hep-2 cancer cell proliferation and Lewis lung carcinoma growth in mice. These results indicated good prospects of using silicon nanoparticles as sensitizers for sonodynamic therapy of tumors.