Email this article Dose Dependence of the Anticoagulant Effect of Intravenously Administered Cellulose Sulfate
- Authors: Drozd N.N.1, Kuznetsova S.A.2, Kalinina T.B.1, Vasilieva N.Y.2
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Affiliations:
- Hematological Research Center, Ministry of Health of the Russian Federation
- Institute of Chemistry and Chemical Technology, Siberian Branch of the Russian Academy of Sciences
- Issue: Vol 160, No 6 (2016)
- Pages: 767-770
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236935
- DOI: https://doi.org/10.1007/s10517-016-3305-6
- ID: 236935
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Abstract
Experiments on rabbits showed that increasing the dose of intravenously administered cellulose sulfate from wheat straw (dynamic viscosity 3.4 cP, sulfur content 14.1%) increased plasma clotting time in some coagulation tests and plasma anticoagulant activity. When cellulose sulfate was administered in the dose of 1 mg/kg, plasma clotting time in the presence of the anticoagulant (5 min after administration) was ~3-fold higher than after saline administration.
About the authors
N. N. Drozd
Hematological Research Center, Ministry of Health of the Russian Federation
Author for correspondence.
Email: nndrozd@mail.ru
Russian Federation, Moscow
S. A. Kuznetsova
Institute of Chemistry and Chemical Technology, Siberian Branch of the Russian Academy of Sciences
Email: nndrozd@mail.ru
Russian Federation, Krasnoyarsk
T. B. Kalinina
Hematological Research Center, Ministry of Health of the Russian Federation
Email: nndrozd@mail.ru
Russian Federation, Moscow
N. Yu. Vasilieva
Institute of Chemistry and Chemical Technology, Siberian Branch of the Russian Academy of Sciences
Email: nndrozd@mail.ru
Russian Federation, Krasnoyarsk
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