Dose Dependence of the Anticoagulant Effect of Intravenously Administered Cellulose Sulfate


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Experiments on rabbits showed that increasing the dose of intravenously administered cellulose sulfate from wheat straw (dynamic viscosity 3.4 cP, sulfur content 14.1%) increased plasma clotting time in some coagulation tests and plasma anticoagulant activity. When cellulose sulfate was administered in the dose of 1 mg/kg, plasma clotting time in the presence of the anticoagulant (5 min after administration) was ~3-fold higher than after saline administration.

作者简介

N. Drozd

Hematological Research Center, Ministry of Health of the Russian Federation

编辑信件的主要联系方式.
Email: nndrozd@mail.ru
俄罗斯联邦, Moscow

S. Kuznetsova

Institute of Chemistry and Chemical Technology, Siberian Branch of the Russian Academy of Sciences

Email: nndrozd@mail.ru
俄罗斯联邦, Krasnoyarsk

T. Kalinina

Hematological Research Center, Ministry of Health of the Russian Federation

Email: nndrozd@mail.ru
俄罗斯联邦, Moscow

N. Vasilieva

Institute of Chemistry and Chemical Technology, Siberian Branch of the Russian Academy of Sciences

Email: nndrozd@mail.ru
俄罗斯联邦, Krasnoyarsk


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