Enviar artigo por via de e-mail Dose Dependence of the Anticoagulant Effect of Intravenously Administered Cellulose Sulfate
- Autores: Drozd N.1, Kuznetsova S.2, Kalinina T.1, Vasilieva N.2
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Afiliações:
- Hematological Research Center, Ministry of Health of the Russian Federation
- Institute of Chemistry and Chemical Technology, Siberian Branch of the Russian Academy of Sciences
- Edição: Volume 160, Nº 6 (2016)
- Páginas: 767-770
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236935
- DOI: https://doi.org/10.1007/s10517-016-3305-6
- ID: 236935
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Resumo
Experiments on rabbits showed that increasing the dose of intravenously administered cellulose sulfate from wheat straw (dynamic viscosity 3.4 cP, sulfur content 14.1%) increased plasma clotting time in some coagulation tests and plasma anticoagulant activity. When cellulose sulfate was administered in the dose of 1 mg/kg, plasma clotting time in the presence of the anticoagulant (5 min after administration) was ~3-fold higher than after saline administration.
Sobre autores
N. Drozd
Hematological Research Center, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: nndrozd@mail.ru
Rússia, Moscow
S. Kuznetsova
Institute of Chemistry and Chemical Technology, Siberian Branch of the Russian Academy of Sciences
Email: nndrozd@mail.ru
Rússia, Krasnoyarsk
T. Kalinina
Hematological Research Center, Ministry of Health of the Russian Federation
Email: nndrozd@mail.ru
Rússia, Moscow
N. Vasilieva
Institute of Chemistry and Chemical Technology, Siberian Branch of the Russian Academy of Sciences
Email: nndrozd@mail.ru
Rússia, Krasnoyarsk
