Soft Tissue Regeneration under the Effect of Wound Coating Based on Chitosan (Natural Biopolymer)
- Authors: Gladkova E.V.1, Babushkina I.V.1, Norkin I.A.1, Mamonova I.A.1, Puchin’yan D.M.1, Konyuchenko E.A.1
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Affiliations:
- Saratov Research Institute of Traumatology and Orthopedics, Ministry of Health of the Russian Federation
- Issue: Vol 160, No 5 (2016)
- Pages: 715-717
- Section: Biotechnologies
- URL: https://journals.rcsi.science/0007-4888/article/view/236915
- DOI: https://doi.org/10.1007/s10517-016-3258-9
- ID: 236915
Cite item
Abstract
We developed wound coating based on natural biopolymer chitosan with additional components (ceruloplasmin, L-asparaginic acid, and glycerol). Experiments on albino male rats demonstrated its regeneratory, antioxidant, and antibacterial effects on wounds involving all layers of the skin. Due to chemical composition and buffer component, the biodegraded wound coating optimizes all phases of the wound process, accelerates by 22-28% the reparative regeneration, and leads to anatomic and functional restoration of injured sites. High absorption capacity recommends its use in the treatment of wounds with profuse exudation.
About the authors
E. V. Gladkova
Saratov Research Institute of Traumatology and Orthopedics, Ministry of Health of the Russian Federation
Author for correspondence.
Email: gladckowa.katya@yandex.ru
Russian Federation, Saratov
I. V. Babushkina
Saratov Research Institute of Traumatology and Orthopedics, Ministry of Health of the Russian Federation
Email: gladckowa.katya@yandex.ru
Russian Federation, Saratov
I. A. Norkin
Saratov Research Institute of Traumatology and Orthopedics, Ministry of Health of the Russian Federation
Email: gladckowa.katya@yandex.ru
Russian Federation, Saratov
I. A. Mamonova
Saratov Research Institute of Traumatology and Orthopedics, Ministry of Health of the Russian Federation
Email: gladckowa.katya@yandex.ru
Russian Federation, Saratov
D. M. Puchin’yan
Saratov Research Institute of Traumatology and Orthopedics, Ministry of Health of the Russian Federation
Email: gladckowa.katya@yandex.ru
Russian Federation, Saratov
E. A. Konyuchenko
Saratov Research Institute of Traumatology and Orthopedics, Ministry of Health of the Russian Federation
Email: gladckowa.katya@yandex.ru
Russian Federation, Saratov