Effect of 5-Fluorouracil on Thymidine Phosphorylase Activity in Model Experiment

M. A. Stashkevich; E. V. Khomutov; Yu. V. Dumanskii; A. G. Matvienko; I. I. Zinkovich

doi:10.1007/s10517-016-3239-z

Effect of 5-Fluorouracil on Thymidine Phosphorylase Activity in Model Experiment

Authors: Stashkevich M.A.¹, Khomutov E.V.¹, Dumanskii Y.V.¹, Matvienko A.G.¹, Zinkovich I.I.¹
Affiliations:
1. Central Research Laboratory, M. Gorky Donetsk National Medical University
Issue: Vol 160, No 5 (2016)
Pages: 646-648
Section: Pharmacology and Toxicology
URL: https://journals.rcsi.science/0007-4888/article/view/236858
DOI: https://doi.org/10.1007/s10517-016-3239-z
ID: 236858

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Abstract

Variations in thymidine phosphorylase activity in rat liver were studied in 1, 3, 6, 12, and 24 h after intraperitoneal bolus injection of 5-fluorouracil. Enzyme activity was measured by HPLC. A 2-fold decrease in enzyme activity was observed 3 h after 5-fluorouracil administration and persisted for 12 h. This additional effect of the cytostatic should be taken into account in choosing chemotherapy protocol.