Enviar artigo por via de e-mail Effect of 5-Fluorouracil on Thymidine Phosphorylase Activity in Model Experiment
- Autores: Stashkevich M.A.1, Khomutov E.V.1, Dumanskii Y.V.1, Matvienko A.G.1, Zinkovich I.I.1
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Afiliações:
- Central Research Laboratory, M. Gorky Donetsk National Medical University
- Edição: Volume 160, Nº 5 (2016)
- Páginas: 646-648
- Seção: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/236858
- DOI: https://doi.org/10.1007/s10517-016-3239-z
- ID: 236858
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Resumo
Variations in thymidine phosphorylase activity in rat liver were studied in 1, 3, 6, 12, and 24 h after intraperitoneal bolus injection of 5-fluorouracil. Enzyme activity was measured by HPLC. A 2-fold decrease in enzyme activity was observed 3 h after 5-fluorouracil administration and persisted for 12 h. This additional effect of the cytostatic should be taken into account in choosing chemotherapy protocol.
Sobre autores
M. Stashkevich
Central Research Laboratory, M. Gorky Donetsk National Medical University
Email: matviyenko.marina@gmail.com
Ucrânia, Donetsk
E. Khomutov
Central Research Laboratory, M. Gorky Donetsk National Medical University
Email: matviyenko.marina@gmail.com
Ucrânia, Donetsk
Yu. Dumanskii
Central Research Laboratory, M. Gorky Donetsk National Medical University
Email: matviyenko.marina@gmail.com
Ucrânia, Donetsk
A. Matvienko
Central Research Laboratory, M. Gorky Donetsk National Medical University
Autor responsável pela correspondência
Email: matviyenko.marina@gmail.com
Ucrânia, Donetsk
I. Zinkovich
Central Research Laboratory, M. Gorky Donetsk National Medical University
Email: matviyenko.marina@gmail.com
Ucrânia, Donetsk
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