Effect of Repeated 1-h Episodes of Immobilization Stress on Activity of Glucocorticoid Metabolism Enzymes in the Liver


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Abstract

Differences in corticosterone level associated with different activity of glucocorticoid-oxidizing enzymes in the liver were revealed in rats exposed to stress. Pro-inflammatory changes in the liver were associated with enhanced CYP3A-dependent monooxygenation.

About the authors

V. E. Tseilikman

South-Ural State Medical University, the Ministry of health of the Russian Federation

Author for correspondence.
Email: vadimed@yandex.ru
Russian Federation, Chelyabinsk

D. A. Kozochkin

South-Ural State Medical University, the Ministry of health of the Russian Federation

Email: vadimed@yandex.ru
Russian Federation, Chelyabinsk

A. I. Sinitskii

South-Ural State Medical University, the Ministry of health of the Russian Federation

Email: vadimed@yandex.ru
Russian Federation, Chelyabinsk

O. B. Tseylikman

South-Ural State University (National Research University)

Email: vadimed@yandex.ru
Russian Federation, Chelyabinsk

M. S. Lapshin

South-Ural State University (National Research University)

Email: vadimed@yandex.ru
Russian Federation, Chelyabinsk

O. V. Kuzina

South-Ural State Medical University, the Ministry of health of the Russian Federation

Email: vadimed@yandex.ru
Russian Federation, Chelyabinsk

M. V. Komel’kova

South-Ural State Medical University, the Ministry of health of the Russian Federation

Email: vadimed@yandex.ru
Russian Federation, Chelyabinsk

I. B. Telesheva

South-Ural State Medical University, the Ministry of health of the Russian Federation

Email: vadimed@yandex.ru
Russian Federation, Chelyabinsk


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