Binding Potency of Heparin Immobilized on Activated Charcoal for DNA Antibodies
- Authors: Snezhkova E.A.1, Tridon A.2, Evrard B.2, Nikolaev V.G.1, Uvarov V.Y.3, Tsimbalyuk R.S.3, Ivanuk A.A.1, Komov V.V.4, Sakhno L.A.1
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Affiliations:
- R. E. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, National Academy of Science of Ukraine
- Faculty of Medicine and Pharmacy, University d’Auvergne
- A. A. Bogomolets National Medical University
- Research Institute of Physicochemical Medicine, Federal Medical-Biological Agency
- Issue: Vol 160, No 4 (2016)
- Pages: 444-447
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236728
- DOI: https://doi.org/10.1007/s10517-016-3192-x
- ID: 236728
Cite item
Abstract
In vitro experiments showed that heparin adsorbed on activated charcoal can bind antibodies raised against native and single-stranded DNA in a diluted sera pool with a high level of these DNA. Thus, heparin used as anticoagulant during hemosorption procedure can demonstrate supplementary therapeutic activity resulting from its interaction with various agents involved in acute and chronic inflammatory reactions such as DNA- and RNA-binding substances, proinflammatory cytokines, complement components, growth factors, etc. Research and development of heparin-containing carbonic adsorbents for the therapy of numerous inflammatory and autoimmune diseases seems to be a promising avenue in hematology.
About the authors
E. A. Snezhkova
R. E. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, National Academy of Science of Ukraine
Author for correspondence.
Email: lisasne@hotmail.com
Ukraine, Kiev
A. Tridon
Faculty of Medicine and Pharmacy, University d’Auvergne
Email: lisasne@hotmail.com
France, Clermont-Ferrand
B. Evrard
Faculty of Medicine and Pharmacy, University d’Auvergne
Email: lisasne@hotmail.com
France, Clermont-Ferrand
V. G. Nikolaev
R. E. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, National Academy of Science of Ukraine
Email: lisasne@hotmail.com
Ukraine, Kiev
V. Yu. Uvarov
A. A. Bogomolets National Medical University
Email: lisasne@hotmail.com
Ukraine, Kiev
R. S. Tsimbalyuk
A. A. Bogomolets National Medical University
Email: lisasne@hotmail.com
Ukraine, Kiev
A. A. Ivanuk
R. E. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, National Academy of Science of Ukraine
Email: lisasne@hotmail.com
Ukraine, Kiev
V. V. Komov
Research Institute of Physicochemical Medicine, Federal Medical-Biological Agency
Email: lisasne@hotmail.com
Russian Federation, Moscow
L. A. Sakhno
R. E. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, National Academy of Science of Ukraine
Email: lisasne@hotmail.com
Ukraine, Kiev
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