Binding Potency of Heparin Immobilized on Activated Charcoal for DNA Antibodies
- 作者: Snezhkova E.1, Tridon A.2, Evrard B.2, Nikolaev V.1, Uvarov V.3, Tsimbalyuk R.3, Ivanuk A.1, Komov V.4, Sakhno L.1
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隶属关系:
- R. E. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, National Academy of Science of Ukraine
- Faculty of Medicine and Pharmacy, University d’Auvergne
- A. A. Bogomolets National Medical University
- Research Institute of Physicochemical Medicine, Federal Medical-Biological Agency
- 期: 卷 160, 编号 4 (2016)
- 页面: 444-447
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236728
- DOI: https://doi.org/10.1007/s10517-016-3192-x
- ID: 236728
如何引用文章
详细
In vitro experiments showed that heparin adsorbed on activated charcoal can bind antibodies raised against native and single-stranded DNA in a diluted sera pool with a high level of these DNA. Thus, heparin used as anticoagulant during hemosorption procedure can demonstrate supplementary therapeutic activity resulting from its interaction with various agents involved in acute and chronic inflammatory reactions such as DNA- and RNA-binding substances, proinflammatory cytokines, complement components, growth factors, etc. Research and development of heparin-containing carbonic adsorbents for the therapy of numerous inflammatory and autoimmune diseases seems to be a promising avenue in hematology.
作者简介
E. Snezhkova
R. E. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, National Academy of Science of Ukraine
编辑信件的主要联系方式.
Email: lisasne@hotmail.com
乌克兰, Kiev
A. Tridon
Faculty of Medicine and Pharmacy, University d’Auvergne
Email: lisasne@hotmail.com
法国, Clermont-Ferrand
B. Evrard
Faculty of Medicine and Pharmacy, University d’Auvergne
Email: lisasne@hotmail.com
法国, Clermont-Ferrand
V. Nikolaev
R. E. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, National Academy of Science of Ukraine
Email: lisasne@hotmail.com
乌克兰, Kiev
V. Uvarov
A. A. Bogomolets National Medical University
Email: lisasne@hotmail.com
乌克兰, Kiev
R. Tsimbalyuk
A. A. Bogomolets National Medical University
Email: lisasne@hotmail.com
乌克兰, Kiev
A. Ivanuk
R. E. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, National Academy of Science of Ukraine
Email: lisasne@hotmail.com
乌克兰, Kiev
V. Komov
Research Institute of Physicochemical Medicine, Federal Medical-Biological Agency
Email: lisasne@hotmail.com
俄罗斯联邦, Moscow
L. Sakhno
R. E. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, National Academy of Science of Ukraine
Email: lisasne@hotmail.com
乌克兰, Kiev
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