Binding Potency of Heparin Immobilized on Activated Charcoal for DNA Antibodies
- Autores: Snezhkova E.1, Tridon A.2, Evrard B.2, Nikolaev V.1, Uvarov V.3, Tsimbalyuk R.3, Ivanuk A.1, Komov V.4, Sakhno L.1
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Afiliações:
- R. E. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, National Academy of Science of Ukraine
- Faculty of Medicine and Pharmacy, University d’Auvergne
- A. A. Bogomolets National Medical University
- Research Institute of Physicochemical Medicine, Federal Medical-Biological Agency
- Edição: Volume 160, Nº 4 (2016)
- Páginas: 444-447
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236728
- DOI: https://doi.org/10.1007/s10517-016-3192-x
- ID: 236728
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Resumo
In vitro experiments showed that heparin adsorbed on activated charcoal can bind antibodies raised against native and single-stranded DNA in a diluted sera pool with a high level of these DNA. Thus, heparin used as anticoagulant during hemosorption procedure can demonstrate supplementary therapeutic activity resulting from its interaction with various agents involved in acute and chronic inflammatory reactions such as DNA- and RNA-binding substances, proinflammatory cytokines, complement components, growth factors, etc. Research and development of heparin-containing carbonic adsorbents for the therapy of numerous inflammatory and autoimmune diseases seems to be a promising avenue in hematology.
Sobre autores
E. Snezhkova
R. E. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, National Academy of Science of Ukraine
Autor responsável pela correspondência
Email: lisasne@hotmail.com
Ucrânia, Kiev
A. Tridon
Faculty of Medicine and Pharmacy, University d’Auvergne
Email: lisasne@hotmail.com
França, Clermont-Ferrand
B. Evrard
Faculty of Medicine and Pharmacy, University d’Auvergne
Email: lisasne@hotmail.com
França, Clermont-Ferrand
V. Nikolaev
R. E. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, National Academy of Science of Ukraine
Email: lisasne@hotmail.com
Ucrânia, Kiev
V. Uvarov
A. A. Bogomolets National Medical University
Email: lisasne@hotmail.com
Ucrânia, Kiev
R. Tsimbalyuk
A. A. Bogomolets National Medical University
Email: lisasne@hotmail.com
Ucrânia, Kiev
A. Ivanuk
R. E. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, National Academy of Science of Ukraine
Email: lisasne@hotmail.com
Ucrânia, Kiev
V. Komov
Research Institute of Physicochemical Medicine, Federal Medical-Biological Agency
Email: lisasne@hotmail.com
Rússia, Moscow
L. Sakhno
R. E. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, National Academy of Science of Ukraine
Email: lisasne@hotmail.com
Ucrânia, Kiev
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