An Experimental Study of the Pharmacokinetics of the Antitumor Drug Aurumacryl
- Авторы: Ostrovskaya L.A.1, Korman D.B.1, Burmiy J.P.2, Kuzmin V.A.1, Bluhterova N.V.1, Fomina M.M.1, Rikova V.A.1, Guliev R.R.1, Abzaeva K.A.3
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Учреждения:
- Emanuel Institute of Biochemical Physics
- Institute of Microelectronic Technology and Ultra-High-Purity Materials
- Favorsky Irkutsk Institute of Chemistry, Siberian Branch
- Выпуск: Том 63, № 3 (2018)
- Страницы: 469-476
- Раздел: Complex Systems Biophysics
- URL: https://journals.rcsi.science/0006-3509/article/view/152661
- DOI: https://doi.org/10.1134/S0006350918030181
- ID: 152661
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Аннотация
The distribution of the antitumor drug aurumacryl (intraperitoneally injected at a dose of 100 mg/kg) in the bodies of animals with Lewis lung carcinoma was studied. The determination of aurumacryl in the tumors and organs (blood, liver, kidneys, lungs, spleen, and brain) of mice was carried out for 48 h by measuring the gold content in the test tissues using inductively coupled plasma mass spectrometry. We found the preferential accumulation of the drug in the kidneys with an extremely low gold content in the brain and a relatively uniform distribution of aurumacryl between the tumor, liver, lung, and spleen tissues.
Об авторах
L. Ostrovskaya
Emanuel Institute of Biochemical Physics
Автор, ответственный за переписку.
Email: larros@list.ru
Россия, ul. Kosygina 4, Moscow, 119334
D. Korman
Emanuel Institute of Biochemical Physics
Email: larros@list.ru
Россия, ul. Kosygina 4, Moscow, 119334
J. Burmiy
Institute of Microelectronic Technology and Ultra-High-Purity Materials
Email: larros@list.ru
Россия, ul. Akademika Osipyana 6, Chernogolovka, 142432
V. Kuzmin
Emanuel Institute of Biochemical Physics
Email: larros@list.ru
Россия, ul. Kosygina 4, Moscow, 119334
N. Bluhterova
Emanuel Institute of Biochemical Physics
Email: larros@list.ru
Россия, ul. Kosygina 4, Moscow, 119334
M. Fomina
Emanuel Institute of Biochemical Physics
Email: larros@list.ru
Россия, ul. Kosygina 4, Moscow, 119334
V. Rikova
Emanuel Institute of Biochemical Physics
Email: larros@list.ru
Россия, ul. Kosygina 4, Moscow, 119334
R. Guliev
Emanuel Institute of Biochemical Physics
Email: larros@list.ru
Россия, ul. Kosygina 4, Moscow, 119334
K. Abzaeva
Favorsky Irkutsk Institute of Chemistry, Siberian Branch
Email: larros@list.ru
Россия, ul. Favorskogo 1, Irkutsk, 664033
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