Отправить статью по E-mail Study of the tissue distribution of potential boron neutron-capture therapy agents based on conjugates of chlorin e6 aminoamide derivatives with boron nanoparticles
- Авторы: Volovetskiy A.B.1, Shilyagina N.Y.1, Dudenkova V.V.1, Pasynkova S.O.2, Ignatova A.A.3,4, Mironov A.F.2, Grin M.A.2, Bregadze V.I.5, Feofanov A.V.3,4, Balalaeva I.V.1, Maslennikova A.V.1,6
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Учреждения:
- Lobachevsky State University of Nizhny Novgorod
- Moscow State University of Fine Chemical Technologies
- Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry
- Moscow State University
- Nesmeyanov Institute of Organoelement Compounds
- Nizhny Novgorod State Medical Academy
- Выпуск: Том 61, № 1 (2016)
- Страницы: 133-138
- Раздел: Biophysics of Complex Systems
- URL: https://journals.rcsi.science/0006-3509/article/view/151928
- DOI: https://doi.org/10.1134/S0006350916010255
- ID: 151928
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Аннотация
Boron neutron-capture therapy of cancer is based on the ability of the 10B isotope to capture thermal neutrons; it is one of the most promising techniques in radiation therapy. The high content and selective accumulation of 10B in the tumor tissue are the most important prerequisites for its efficacy. The purpose of this study was to determine the biodistribution of cobalt bis(dicarbollide) conjugates with chlorin e6 amino amide derivatives. Experiments were carried out in Balb/c mice with transplanted CT-26 murine colon carcinoma. Boron-containing conjugates were injected into the tail vein at a dose of 10 mg/kg. The conjugate accumulation in tumor tissue and organs was studied by laser scanning microscopy. Excitation was performed at the wavelength of 514 nm; the signals were recorded in the range of 560–710 nm in increments of 10 nm. To evaluate the amount of the boron conjugate, we calculated the intensity of the fluorescence signal of the samples under investigation. At 3 h after administration of the agent, a high level of fluorescence was observed in the liver, spleen, and lung. The tumor/muscle accumulation ratio was approximately 3. The study demonstrated that boron derivatives of chlorin e6 are promising agents for boron neutron-capture therapy.
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A. Volovetskiy
Lobachevsky State University of Nizhny Novgorod
Автор, ответственный за переписку.
Email: voloveckiy91@gmail.com
Россия, pr. Gagarina 23, Nizhny Novgorod, 603950
N. Shilyagina
Lobachevsky State University of Nizhny Novgorod
Email: voloveckiy91@gmail.com
Россия, pr. Gagarina 23, Nizhny Novgorod, 603950
V. Dudenkova
Lobachevsky State University of Nizhny Novgorod
Email: voloveckiy91@gmail.com
Россия, pr. Gagarina 23, Nizhny Novgorod, 603950
S. Pasynkova
Moscow State University of Fine Chemical Technologies
Email: voloveckiy91@gmail.com
Россия, pr. Vernadskogo 86, Moscow, 119571
A. Ignatova
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry; Moscow State University
Email: voloveckiy91@gmail.com
Россия, ul. Mikluho-Maklaya 16/10, Moscow, 117997; Moscow, 119234
A. Mironov
Moscow State University of Fine Chemical Technologies
Email: voloveckiy91@gmail.com
Россия, pr. Vernadskogo 86, Moscow, 119571
M. Grin
Moscow State University of Fine Chemical Technologies
Email: voloveckiy91@gmail.com
Россия, pr. Vernadskogo 86, Moscow, 119571
V. Bregadze
Nesmeyanov Institute of Organoelement Compounds
Email: voloveckiy91@gmail.com
Россия, ul. Vavilova 28, Moscow, 119991
A. Feofanov
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry; Moscow State University
Email: voloveckiy91@gmail.com
Россия, ul. Mikluho-Maklaya 16/10, Moscow, 117997; Moscow, 119234
I. Balalaeva
Lobachevsky State University of Nizhny Novgorod
Email: voloveckiy91@gmail.com
Россия, pr. Gagarina 23, Nizhny Novgorod, 603950
A. Maslennikova
Lobachevsky State University of Nizhny Novgorod; Nizhny Novgorod State Medical Academy
Email: voloveckiy91@gmail.com
Россия, pr. Gagarina 23, Nizhny Novgorod, 603950; pl. Minina i Pozharskogo 10/1, Nizhny Novgorod, 603005
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