Assessment of the Biological Efficiency of 450 MeV/Nucleon Accelerated Carbon Ions in the U-70 Accelerator According to the Criterion of Mouse Survival
- Авторлар: Rozanova O.1, Smirnova E.1, Dyukina A.1, Belyakova T.2, Strelnikova N.2, Sorokina S.1, Pikalov V.3, Zaichkina S.1
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Мекемелер:
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- Physico-Technical Center, Lebedev Physical Institute, Russian Academy of Sciences
- Institute of High Energy Physics of the National Research Center “Kurchatov Institute”
- Шығарылым: Том 64, № 6 (2019)
- Беттер: 991-998
- Бөлім: Complex Systems Biophysics
- URL: https://journals.rcsi.science/0006-3509/article/view/153160
- DOI: https://doi.org/10.1134/S000635091906023X
- ID: 153160
Дәйексөз келтіру
Аннотация
Abstract—The coefficients of the relative biological efficiency of a carbon ion beam with an energy of 450 MeV/nucleon upon the irradiation of mice at a dose of 6.5 Gy in different parts of the Bragg curve have been determined by the 30-day survival test, the dynamics of death, and the average life expectancy of mice in comparison with exposure to X-ray radiation. The integral value of the coefficients of the relative biological efficiency of carbon ions upon irradiation before the Bragg peak is 0.8, in the spread-out Bragg peak it is 1.5, and after the Bragg peak, it is 0.7. The value of the relative biological efficiency in the modified Bragg peak, as calculated by the ratio of doses that lead to the death of 50% of the animals, was 2.9. Changes of the width of the modified Bragg peak did not affect the death rate of the animals.
Негізгі сөздер
Авторлар туралы
O. Rozanova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: rozanova.iteb@gmail.com
Ресей, Pushchino, Moscow oblast, 142290
E. Smirnova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: rozanova.iteb@gmail.com
Ресей, Pushchino, Moscow oblast, 142290
A. Dyukina
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: rozanova.iteb@gmail.com
Ресей, Pushchino, Moscow oblast, 142290
T. Belyakova
Physico-Technical Center, Lebedev Physical Institute, Russian Academy of Sciences
Email: rozanova.iteb@gmail.com
Ресей, Protvino, Moscow oblast, 142281
N. Strelnikova
Physico-Technical Center, Lebedev Physical Institute, Russian Academy of Sciences
Email: rozanova.iteb@gmail.com
Ресей, Protvino, Moscow oblast, 142281
S. Sorokina
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: rozanova.iteb@gmail.com
Ресей, Pushchino, Moscow oblast, 142290
V. Pikalov
Institute of High Energy Physics of the National Research Center “Kurchatov Institute”
Email: rozanova.iteb@gmail.com
Ресей, Protvino, Moscow oblast, 142281
S. Zaichkina
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: rozanova.iteb@gmail.com
Ресей, Pushchino, Moscow oblast, 142290