Assessment of the Biological Efficiency of 450 MeV/Nucleon Accelerated Carbon Ions in the U-70 Accelerator According to the Criterion of Mouse Survival
- Authors: Rozanova O.M.1, Smirnova E.N.1, Dyukina A.R.1, Belyakova T.A.2, Strelnikova N.S.2, Sorokina S.S.1, Pikalov V.A.3, Zaichkina S.I.1
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Affiliations:
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- Physico-Technical Center, Lebedev Physical Institute, Russian Academy of Sciences
- Institute of High Energy Physics of the National Research Center “Kurchatov Institute”
- Issue: Vol 64, No 6 (2019)
- Pages: 991-998
- Section: Complex Systems Biophysics
- URL: https://journals.rcsi.science/0006-3509/article/view/153160
- DOI: https://doi.org/10.1134/S000635091906023X
- ID: 153160
Cite item
Abstract
Abstract—The coefficients of the relative biological efficiency of a carbon ion beam with an energy of 450 MeV/nucleon upon the irradiation of mice at a dose of 6.5 Gy in different parts of the Bragg curve have been determined by the 30-day survival test, the dynamics of death, and the average life expectancy of mice in comparison with exposure to X-ray radiation. The integral value of the coefficients of the relative biological efficiency of carbon ions upon irradiation before the Bragg peak is 0.8, in the spread-out Bragg peak it is 1.5, and after the Bragg peak, it is 0.7. The value of the relative biological efficiency in the modified Bragg peak, as calculated by the ratio of doses that lead to the death of 50% of the animals, was 2.9. Changes of the width of the modified Bragg peak did not affect the death rate of the animals.
About the authors
O. M. Rozanova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Author for correspondence.
Email: rozanova.iteb@gmail.com
Russian Federation, Pushchino, Moscow oblast, 142290
E. N. Smirnova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: rozanova.iteb@gmail.com
Russian Federation, Pushchino, Moscow oblast, 142290
A. R. Dyukina
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: rozanova.iteb@gmail.com
Russian Federation, Pushchino, Moscow oblast, 142290
T. A. Belyakova
Physico-Technical Center, Lebedev Physical Institute, Russian Academy of Sciences
Email: rozanova.iteb@gmail.com
Russian Federation, Protvino, Moscow oblast, 142281
N. S. Strelnikova
Physico-Technical Center, Lebedev Physical Institute, Russian Academy of Sciences
Email: rozanova.iteb@gmail.com
Russian Federation, Protvino, Moscow oblast, 142281
S. S. Sorokina
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: rozanova.iteb@gmail.com
Russian Federation, Pushchino, Moscow oblast, 142290
V. A. Pikalov
Institute of High Energy Physics of the National Research Center “Kurchatov Institute”
Email: rozanova.iteb@gmail.com
Russian Federation, Protvino, Moscow oblast, 142281
S. I. Zaichkina
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: rozanova.iteb@gmail.com
Russian Federation, Pushchino, Moscow oblast, 142290