The Antitumor Activity of Dinitrosyl Iron Complexes with Mercaptosuccinate in Murine Solid Tumor Models
- Autores: Vanin A.1,2, Ostrovskaya L.3, Korman D.3, Bluchterova N.3, Rykova V.3, Fomina M.3
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Afiliações:
- Semenov Institute of Chemical Physics, Russian Academy of Sciences
- Institute of Regenerative Medicine, Sechenov First Moscow State Medical University
- Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Edição: Volume 64, Nº 6 (2019)
- Páginas: 999-1002
- Seção: Complex Systems Biophysics
- URL: https://journals.rcsi.science/0006-3509/article/view/153162
- DOI: https://doi.org/10.1134/S0006350919060228
- ID: 153162
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Resumo
The antitumor activity of the binuclear form of dinitrosyl iron complexes with mercaptosuccinate administered intravenously was studied in murine models of solid tumors: Lewis lung carcinoma and Acatol adenocarcinoma. The maximum effect, suppression of tumor growth by 65% in comparison to the control for Lewis carcinoma, was observed for a course of six intravenous injections in a daily dose of 2.5 μM/kg administered every 2 or 3 days over the period of days 1–17 after tumor transplantation.
Sobre autores
A. Vanin
Semenov Institute of Chemical Physics, Russian Academy of Sciences; Institute of Regenerative Medicine, Sechenov First Moscow State Medical University
Autor responsável pela correspondência
Email: vanin@polymer.chph.ras.ru
Rússia, Moscow, 119334; Moscow, 119991
L. Ostrovskaya
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: vanin@polymer.chph.ras.ru
Rússia, Moscow, 119334
D. Korman
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: vanin@polymer.chph.ras.ru
Rússia, Moscow, 119334
N. Bluchterova
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: vanin@polymer.chph.ras.ru
Rússia, Moscow, 119334
V. Rykova
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: vanin@polymer.chph.ras.ru
Rússia, Moscow, 119334
M. Fomina
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: vanin@polymer.chph.ras.ru
Rússia, Moscow, 119334