Mitochondrial DNA Deletion in Offspring of Female Mice Exposed to X-Rays
- Authors: Lomaeva M.G.1, Antipova V.N.1, Bezlepkin V.G.1, Gaziev A.I.1
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Affiliations:
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- Issue: Vol 64, No 4 (2019)
- Pages: 528-532
- Section: Molecular Biophysics
- URL: https://journals.rcsi.science/0006-3509/article/view/152999
- DOI: https://doi.org/10.1134/S0006350919040109
- ID: 152999
Cite item
Abstract
Abstract—The effects of X-ray exposure on the mitochondrial genome were studied in the offspring of female mice exposed in the preconception period at doses of 0.5 and 2 Gy. Radiation effects were evaluated by the proportion of offspring with a 4974-bp mtDNA deletion. The results showed that irradiation of female mice at these doses did not increase the proportion of offspring with the mtDNA deletion in the brain, spleen, and peripheral blood cells.
Keywords
About the authors
M. G. Lomaeva
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Author for correspondence.
Email: lommg1@gmail.com
Russian Federation, Pushchino, Moscow oblast, 142290
V. N. Antipova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: lommg1@gmail.com
Russian Federation, Pushchino, Moscow oblast, 142290
V. G. Bezlepkin
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: lommg1@gmail.com
Russian Federation, Pushchino, Moscow oblast, 142290
A. I. Gaziev
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: lommg1@gmail.com
Russian Federation, Pushchino, Moscow oblast, 142290
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