Mitochondrial DNA Deletion in Offspring of Female Mice Exposed to X-Rays


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Abstract

Abstract—The effects of X-ray exposure on the mitochondrial genome were studied in the offspring of female mice exposed in the preconception period at doses of 0.5 and 2 Gy. Radiation effects were evaluated by the proportion of offspring with a 4974-bp mtDNA deletion. The results showed that irradiation of female mice at these doses did not increase the proportion of offspring with the mtDNA deletion in the brain, spleen, and peripheral blood cells.

About the authors

M. G. Lomaeva

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

Author for correspondence.
Email: lommg1@gmail.com
Russian Federation, Pushchino, Moscow oblast, 142290

V. N. Antipova

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

Email: lommg1@gmail.com
Russian Federation, Pushchino, Moscow oblast, 142290

V. G. Bezlepkin

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

Email: lommg1@gmail.com
Russian Federation, Pushchino, Moscow oblast, 142290

A. I. Gaziev

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

Email: lommg1@gmail.com
Russian Federation, Pushchino, Moscow oblast, 142290

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