The Influence of Chemotherapy on the Progression of a Biclonal Tumor: Analysis Using Mathematical Modeling

Abstract

The effect of chemotherapy on the composition of a solid biclonal tumor was studied using mathematical modeling. In a solid biclonal tumor, cells of one population possess greater poliferation rate and cells of the other population have a higher level of intrinsic motility. It was shown that at low sensitivity of cells to a chemotherapeutic drug, chemotherapy increases the area in the space of parameters where the rapidly proliferating population dominates. During high-dose chemotherapy, this effect is weaker and in the other part of the parametric space a reverse shift of the dominant population occurs of the dominant population from the rapidly proliferating one to the more motile one.