Alterations of Antioxidant and Oxygen Transport Properties of Blood in Adenocarcinoma-Bearing Mice during Chemotherapy

A. A. Baizhumanov; V. V. Elagin; E. S. Tkhor; E. Y. Parshina; A. I. Yusipovich; M. A. Silicheva; G. V. Maksimov

doi:10.1134/S0006350918020045

Alterations of Antioxidant and Oxygen Transport Properties of Blood in Adenocarcinoma-Bearing Mice during Chemotherapy

Authors: Baizhumanov A.A.¹, Elagin V.V.², Tkhor E.S.¹, Parshina E.Y.¹, Yusipovich A.I.¹, Silicheva M.A.¹, Maksimov G.V.¹
Affiliations:
1. Department of Biology
2. Institute of Biomedical Technologies
Issue: Vol 63, No 2 (2018)
Pages: 233-236
Section: Complex Systems Biophysics
URL: https://journals.rcsi.science/0006-3509/article/view/152566
DOI: https://doi.org/10.1134/S0006350918020045
ID: 152566

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Abstract

The influence of murine intestinal adenocarcinoma on the antioxidant status and hemoglobin content in the blood was analyzed. Murine adenocarcinoma was accompanied with a decrease of the nonprotein thiol concentration and an increase in ceruloplasmin. A conformational change in the globin molecule but not in the heme group was revealed in the hemoglobin molecule. The changes in the protein appear to be caused by nonspecific damage that results from the processes of peroxidation.