Simulating Temporal Organization of Histogenesis

Resumo

The paper discusses a discrete model of hepatic plate histogenesis based on the dissymmetry distribution times of cell cycles. The model is based on the assumption of the finality of cell time as an internal parameter of a single cycle of biological spacetime. Another assumption is the divisibility of maternal cell time in half between daughter cells, which makes it possible to consider the stem cell macrocycle in histogenesis as a system of nested cell cycles with progressively decreasing time. In addition, it was expected that at each step of cell division in homogeneous histogenesis, a asymmetric distribution of reference of cell time management by mitosis, which is related to the intron region of the genome. The obtained numerical model agrees with the characteristics of the architectonics of the liver, the limited number of cell divisions, and the frequency distribution of mitosis and aging as the extinction process of cells with short cycles.