Volume 51, Nº 6 (2018)

We present here results obtained during the developmental construction of a selective biological sensor based on carbon nanotubes chemically modified with specific aptamers. The sensory layer, consisting of a film of carbon nanotubes, on a flexible polymer substrate, provides high sensitivity for assay of the target proteins. The responses of the sensory structures to the target protein − thrombin and a reference protein, albumin − were studied. Selective estimation of thrombin after exposure of the sensor to albumin was demonstrated.

We describe a method for increasing the effectiveness of surgery to position flow-diverter stents into cerebral arteries with aneurysms based on the combined use of mathematical modeling of hemodynamics and compression elastography. Approaches to determining Young's modulus and the Poisson's ratio for phantom of cerebral artery walls on the basis of endoscopic optical coherence tomography data were developed and tested. The applicability of this method was verified using a model of internal carotid artery aneurysm using a mathematical hemodynamic model taking into account the mechanical properties of the cerebral artery wall.

A distribution law was found for the selective correlation coefficient \( \widehat{\uprho} \). An expression was obtained to find the boundary ρ_bound at which the selective correlation coefficient \( \widehat{\uprho} \) for comparison of the similarity of cardiac complexes is not exceeded with a probability of β = 0.005.

A hardware and software system for donor liver perfusion is described. Both standard and adaptive algorithms for perfusion control in the process of liver function restoration are described. The adaptive algorithm is based on a mathematical model of machine perfusion. It provides complete perfusion and allows blood cell injuries that often accompany the standard perfusion procedure to be avoided.

The efficiency of treatment of chronic prostatitis can be increased using mathematical models for adjusting the amplitude and the frequency of the therapeutic electromagnetic effect according to the parameters of blood supply to the prostate.

A test bench for performance validation of an artificial pancreas system is described. The test bench allows simulating an increase or a decrease in blood glucose by automated mixing of glucose-containing test solution. It also provides validation of the blood glucose prediction algorithm. The test bench consists of an electrical subsystem and a hydraulic subsystem that are controlled from PC user interface. It provides blood glucose measurement and prediction with an error of <5% and the accuracy of insulin dosing of 0.05 μL.

The effect of the symmetrical coil couple geometry on the value of lateral coil misalignment that corresponds to zero coupling in inductive energy transfer systems was studied. It was shown that the distance between coil turns and the number of coil turns have rather small effect on the zero-coupling distance. Increasing the outer diameter of the coils was shown to be the only way to increase the zero-coupling distance at given parameters of the system. It was found that changes in the outer diameter of the coils had more significant effect on the zero-coupling distance when the outer diameter was more than twice as great as the inner diameter.

Computerized emission tomography is an effective method for the diagnosis of pathological states in the human body. A new emission tomography approach was developed involving the use of multiplexed measurement systems (MMS). An iterative algorithm implementing the back projection method for emission tomography based on MMS was developed using hexagonal coding collimators. Numerical modeling demonstrated the validity of the proposed method.

The effect of the shapes of the transmitter and receiver antennas on the voltage gain and the bandwidth of the wireless channel of inductive powering units was evaluated. Antennas with square and round coils were compared. It was shown that under otherwise identical conditions square-coil antennas provided higher voltage gain and broader bandwidth of the wireless channel.