Mitochondria as a signaling Hub and target for phenoptosis shutdown
- 作者: Zolotukhin P.1, Belanova A.1, Prazdnova E.1, Mazanko M.1, Batiushin M.1, Chmyhalo V.1, Chistyakov V.1
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隶属关系:
- Southern Federal University
- 期: 卷 81, 编号 4 (2016)
- 页面: 329-337
- 栏目: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/150823
- DOI: https://doi.org/10.1134/S0006297916040039
- ID: 150823
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详细
Mitochondria have long been studied as the main energy source and one of the most important generators of reactive oxygen species in the eukaryotic cell. Yet, new data suggest mitochondria serve as a powerful cellular regulator, pathway trigger, and signal hub. Some of these crucial mitochondrial functions appear to be associated with RNP-granules. Deep and versatile involvement of mitochondria in general cellular regulation may be the legacy of parasitic behavior of the ancestors of mitochondria in the host cells. In this regard, we also discuss here the perspectives of using mitochondria-targeted compounds for systemic correction of phenoptotic shifts.
作者简介
P. Zolotukhin
Southern Federal University
Email: vladimirchi@sfedu.ru
俄罗斯联邦, Rostov-on-Don, 344090
A. Belanova
Southern Federal University
Email: vladimirchi@sfedu.ru
俄罗斯联邦, Rostov-on-Don, 344090
E. Prazdnova
Southern Federal University
Email: vladimirchi@sfedu.ru
俄罗斯联邦, Rostov-on-Don, 344090
M. Mazanko
Southern Federal University
Email: vladimirchi@sfedu.ru
俄罗斯联邦, Rostov-on-Don, 344090
M. Batiushin
Southern Federal University
Email: vladimirchi@sfedu.ru
俄罗斯联邦, Rostov-on-Don, 344090
V. Chmyhalo
Southern Federal University
Email: vladimirchi@sfedu.ru
俄罗斯联邦, Rostov-on-Don, 344090
V. Chistyakov
Southern Federal University
编辑信件的主要联系方式.
Email: vladimirchi@sfedu.ru
俄罗斯联邦, Rostov-on-Don, 344090