Mitochondria as a signaling Hub and target for phenoptosis shutdown
- Authors: Zolotukhin P.V.1, Belanova A.A.1, Prazdnova E.V.1, Mazanko M.S.1, Batiushin M.M.1, Chmyhalo V.K.1, Chistyakov V.A.1
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Affiliations:
- Southern Federal University
- Issue: Vol 81, No 4 (2016)
- Pages: 329-337
- Section: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/150823
- DOI: https://doi.org/10.1134/S0006297916040039
- ID: 150823
Cite item
Abstract
Mitochondria have long been studied as the main energy source and one of the most important generators of reactive oxygen species in the eukaryotic cell. Yet, new data suggest mitochondria serve as a powerful cellular regulator, pathway trigger, and signal hub. Some of these crucial mitochondrial functions appear to be associated with RNP-granules. Deep and versatile involvement of mitochondria in general cellular regulation may be the legacy of parasitic behavior of the ancestors of mitochondria in the host cells. In this regard, we also discuss here the perspectives of using mitochondria-targeted compounds for systemic correction of phenoptotic shifts.
About the authors
P. V. Zolotukhin
Southern Federal University
Email: vladimirchi@sfedu.ru
Russian Federation, Rostov-on-Don, 344090
A. A. Belanova
Southern Federal University
Email: vladimirchi@sfedu.ru
Russian Federation, Rostov-on-Don, 344090
E. V. Prazdnova
Southern Federal University
Email: vladimirchi@sfedu.ru
Russian Federation, Rostov-on-Don, 344090
M. S. Mazanko
Southern Federal University
Email: vladimirchi@sfedu.ru
Russian Federation, Rostov-on-Don, 344090
M. M. Batiushin
Southern Federal University
Email: vladimirchi@sfedu.ru
Russian Federation, Rostov-on-Don, 344090
V. K. Chmyhalo
Southern Federal University
Email: vladimirchi@sfedu.ru
Russian Federation, Rostov-on-Don, 344090
V. A. Chistyakov
Southern Federal University
Author for correspondence.
Email: vladimirchi@sfedu.ru
Russian Federation, Rostov-on-Don, 344090