Mitochondria as a signaling Hub and target for phenoptosis shutdown
- Авторлар: Zolotukhin P.1, Belanova A.1, Prazdnova E.1, Mazanko M.1, Batiushin M.1, Chmyhalo V.1, Chistyakov V.1
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Мекемелер:
- Southern Federal University
- Шығарылым: Том 81, № 4 (2016)
- Беттер: 329-337
- Бөлім: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/150823
- DOI: https://doi.org/10.1134/S0006297916040039
- ID: 150823
Дәйексөз келтіру
Аннотация
Mitochondria have long been studied as the main energy source and one of the most important generators of reactive oxygen species in the eukaryotic cell. Yet, new data suggest mitochondria serve as a powerful cellular regulator, pathway trigger, and signal hub. Some of these crucial mitochondrial functions appear to be associated with RNP-granules. Deep and versatile involvement of mitochondria in general cellular regulation may be the legacy of parasitic behavior of the ancestors of mitochondria in the host cells. In this regard, we also discuss here the perspectives of using mitochondria-targeted compounds for systemic correction of phenoptotic shifts.
Негізгі сөздер
Авторлар туралы
P. Zolotukhin
Southern Federal University
Email: vladimirchi@sfedu.ru
Ресей, Rostov-on-Don, 344090
A. Belanova
Southern Federal University
Email: vladimirchi@sfedu.ru
Ресей, Rostov-on-Don, 344090
E. Prazdnova
Southern Federal University
Email: vladimirchi@sfedu.ru
Ресей, Rostov-on-Don, 344090
M. Mazanko
Southern Federal University
Email: vladimirchi@sfedu.ru
Ресей, Rostov-on-Don, 344090
M. Batiushin
Southern Federal University
Email: vladimirchi@sfedu.ru
Ресей, Rostov-on-Don, 344090
V. Chmyhalo
Southern Federal University
Email: vladimirchi@sfedu.ru
Ресей, Rostov-on-Don, 344090
V. Chistyakov
Southern Federal University
Хат алмасуға жауапты Автор.
Email: vladimirchi@sfedu.ru
Ресей, Rostov-on-Don, 344090