Effect of alpha-fetoprotein on lifespan of old mice
- Авторы: Krut’ko V.1,2, Dontsov V.1, Khalyavkin A.1
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Учреждения:
- Institute for Systems Analysis, Federal Research Center “Computer Science and Control”
- Sechenov First Moscow State Medical University
- Выпуск: Том 81, № 12 (2016)
- Страницы: 1477-1479
- Раздел: Phenoptosis (Special Issue)
- URL: https://journals.rcsi.science/0006-2979/article/view/151142
- DOI: https://doi.org/10.1134/S0006297916120087
- ID: 151142
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Аннотация
Alpha-fetoprotein (AFP) is one of the best-known embryo-specific proteins. It is used to diagnose fetal abnormalities and tumors of the gastrointestinal tract and liver. AFP has pronounced immunotropic and detoxifying effect and a direct apoptotic effect on tumor cells. The treatment of mice at the oldest age in our experiments with AFP dramatically increased the survival and markedly increased the relative weight of immunotropic organs, apparently due to the general effect of AFP in improving functions of tissues and detoxifying actions. It also improved appearance and the relative weight of internal organs with a reduced age of autoaggression.
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Об авторах
V. Krut’ko
Institute for Systems Analysis, Federal Research Center “Computer Science and Control”; Sechenov First Moscow State Medical University
Email: dontsovvi@mail.ru
Россия, Moscow, 117312; Moscow, 119991
V. Dontsov
Institute for Systems Analysis, Federal Research Center “Computer Science and Control”
Автор, ответственный за переписку.
Email: dontsovvi@mail.ru
Россия, Moscow, 117312
A. Khalyavkin
Institute for Systems Analysis, Federal Research Center “Computer Science and Control”
Email: dontsovvi@mail.ru
Россия, Moscow, 117312