Effect of alpha-fetoprotein on lifespan of old mice
- Authors: Krut’ko V.N.1,2, Dontsov V.I.1, Khalyavkin A.V.1
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Affiliations:
- Institute for Systems Analysis, Federal Research Center “Computer Science and Control”
- Sechenov First Moscow State Medical University
- Issue: Vol 81, No 12 (2016)
- Pages: 1477-1479
- Section: Phenoptosis (Special Issue)
- URL: https://journals.rcsi.science/0006-2979/article/view/151142
- DOI: https://doi.org/10.1134/S0006297916120087
- ID: 151142
Cite item
Abstract
Alpha-fetoprotein (AFP) is one of the best-known embryo-specific proteins. It is used to diagnose fetal abnormalities and tumors of the gastrointestinal tract and liver. AFP has pronounced immunotropic and detoxifying effect and a direct apoptotic effect on tumor cells. The treatment of mice at the oldest age in our experiments with AFP dramatically increased the survival and markedly increased the relative weight of immunotropic organs, apparently due to the general effect of AFP in improving functions of tissues and detoxifying actions. It also improved appearance and the relative weight of internal organs with a reduced age of autoaggression.
Keywords
About the authors
V. N. Krut’ko
Institute for Systems Analysis, Federal Research Center “Computer Science and Control”; Sechenov First Moscow State Medical University
Email: dontsovvi@mail.ru
Russian Federation, Moscow, 117312; Moscow, 119991
V. I. Dontsov
Institute for Systems Analysis, Federal Research Center “Computer Science and Control”
Author for correspondence.
Email: dontsovvi@mail.ru
Russian Federation, Moscow, 117312
A. V. Khalyavkin
Institute for Systems Analysis, Federal Research Center “Computer Science and Control”
Email: dontsovvi@mail.ru
Russian Federation, Moscow, 117312
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