Effects of mitochondrial antioxidant SkQ1 on biochemical and behavioral parameters in a Parkinsonism model in mice
- Autores: Pavshintsev V.1,2, Podshivalova L.2, Frolova O.1, Belopolskaya M.1, Averina O.2, Kushnir E.1, Marmiy N.1, Lovat M.1,2
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Afiliações:
- Institute of Mitoengineering
- Lomonosov Moscow State University
- Edição: Volume 82, Nº 12 (2017)
- Páginas: 1513-1520
- Seção: Article
- URL: https://journals.rcsi.science/0006-2979/article/view/151540
- DOI: https://doi.org/10.1134/S0006297917120100
- ID: 151540
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Resumo
According to one hypothesis, Parkinson’s disease pathogenesis is largely caused by dopamine catabolism that is catalyzed on mitochondrial membranes by monoamine oxidase. Reactive oxygen species are formed as a byproduct of these reactions, which can lead to mitochondrial damage followed by cell degeneration and death. In this study, we investigated the effects of administration of the mitochondrial antioxidant SkQ1 on biochemical, immunohistochemical, and behavioral parameters in a Parkinson-like condition caused by protoxin MPTP injections in C57BL/6 mice. SkQ1 administration increased dopamine quantity and decreased signs of sensory-motor deficiency as well as destruction of dopaminergic neurons in the substantia nigra and ventral tegmental area in mice with the Parkinson-like condition.
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Sobre autores
V. Pavshintsev
Institute of Mitoengineering; Lomonosov Moscow State University
Autor responsável pela correspondência
Email: vsevolodpav@mail.ru
Rússia, Moscow, 119234; Moscow, 119234
L. Podshivalova
Lomonosov Moscow State University
Email: vsevolodpav@mail.ru
Rússia, Moscow, 119234
O. Frolova
Institute of Mitoengineering
Email: vsevolodpav@mail.ru
Rússia, Moscow, 119234
M. Belopolskaya
Institute of Mitoengineering
Email: vsevolodpav@mail.ru
Rússia, Moscow, 119234
O. Averina
Lomonosov Moscow State University
Email: vsevolodpav@mail.ru
Rússia, Moscow, 119234
E. Kushnir
Institute of Mitoengineering
Email: vsevolodpav@mail.ru
Rússia, Moscow, 119234
N. Marmiy
Institute of Mitoengineering
Email: vsevolodpav@mail.ru
Rússia, Moscow, 119234
M. Lovat
Institute of Mitoengineering; Lomonosov Moscow State University
Email: vsevolodpav@mail.ru
Rússia, Moscow, 119234; Moscow, 119234
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