Effects of mitochondrial antioxidant SkQ1 on biochemical and behavioral parameters in a Parkinsonism model in mice
- 作者: Pavshintsev V.1,2, Podshivalova L.2, Frolova O.1, Belopolskaya M.1, Averina O.2, Kushnir E.1, Marmiy N.1, Lovat M.1,2
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隶属关系:
- Institute of Mitoengineering
- Lomonosov Moscow State University
- 期: 卷 82, 编号 12 (2017)
- 页面: 1513-1520
- 栏目: Article
- URL: https://journals.rcsi.science/0006-2979/article/view/151540
- DOI: https://doi.org/10.1134/S0006297917120100
- ID: 151540
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详细
According to one hypothesis, Parkinson’s disease pathogenesis is largely caused by dopamine catabolism that is catalyzed on mitochondrial membranes by monoamine oxidase. Reactive oxygen species are formed as a byproduct of these reactions, which can lead to mitochondrial damage followed by cell degeneration and death. In this study, we investigated the effects of administration of the mitochondrial antioxidant SkQ1 on biochemical, immunohistochemical, and behavioral parameters in a Parkinson-like condition caused by protoxin MPTP injections in C57BL/6 mice. SkQ1 administration increased dopamine quantity and decreased signs of sensory-motor deficiency as well as destruction of dopaminergic neurons in the substantia nigra and ventral tegmental area in mice with the Parkinson-like condition.
作者简介
V. Pavshintsev
Institute of Mitoengineering; Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: vsevolodpav@mail.ru
俄罗斯联邦, Moscow, 119234; Moscow, 119234
L. Podshivalova
Lomonosov Moscow State University
Email: vsevolodpav@mail.ru
俄罗斯联邦, Moscow, 119234
O. Frolova
Institute of Mitoengineering
Email: vsevolodpav@mail.ru
俄罗斯联邦, Moscow, 119234
M. Belopolskaya
Institute of Mitoengineering
Email: vsevolodpav@mail.ru
俄罗斯联邦, Moscow, 119234
O. Averina
Lomonosov Moscow State University
Email: vsevolodpav@mail.ru
俄罗斯联邦, Moscow, 119234
E. Kushnir
Institute of Mitoengineering
Email: vsevolodpav@mail.ru
俄罗斯联邦, Moscow, 119234
N. Marmiy
Institute of Mitoengineering
Email: vsevolodpav@mail.ru
俄罗斯联邦, Moscow, 119234
M. Lovat
Institute of Mitoengineering; Lomonosov Moscow State University
Email: vsevolodpav@mail.ru
俄罗斯联邦, Moscow, 119234; Moscow, 119234
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