Effects of mitochondrial antioxidant SkQ1 on biochemical and behavioral parameters in a Parkinsonism model in mice
- Authors: Pavshintsev V.V.1,2, Podshivalova L.S.2, Frolova O.Y.1, Belopolskaya M.V.1, Averina O.A.2, Kushnir E.A.1, Marmiy N.V.1, Lovat M.L.1,2
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Affiliations:
- Institute of Mitoengineering
- Lomonosov Moscow State University
- Issue: Vol 82, No 12 (2017)
- Pages: 1513-1520
- Section: Article
- URL: https://journals.rcsi.science/0006-2979/article/view/151540
- DOI: https://doi.org/10.1134/S0006297917120100
- ID: 151540
Cite item
Abstract
According to one hypothesis, Parkinson’s disease pathogenesis is largely caused by dopamine catabolism that is catalyzed on mitochondrial membranes by monoamine oxidase. Reactive oxygen species are formed as a byproduct of these reactions, which can lead to mitochondrial damage followed by cell degeneration and death. In this study, we investigated the effects of administration of the mitochondrial antioxidant SkQ1 on biochemical, immunohistochemical, and behavioral parameters in a Parkinson-like condition caused by protoxin MPTP injections in C57BL/6 mice. SkQ1 administration increased dopamine quantity and decreased signs of sensory-motor deficiency as well as destruction of dopaminergic neurons in the substantia nigra and ventral tegmental area in mice with the Parkinson-like condition.
About the authors
V. V. Pavshintsev
Institute of Mitoengineering; Lomonosov Moscow State University
Author for correspondence.
Email: vsevolodpav@mail.ru
Russian Federation, Moscow, 119234; Moscow, 119234
L. S. Podshivalova
Lomonosov Moscow State University
Email: vsevolodpav@mail.ru
Russian Federation, Moscow, 119234
O. Y. Frolova
Institute of Mitoengineering
Email: vsevolodpav@mail.ru
Russian Federation, Moscow, 119234
M. V. Belopolskaya
Institute of Mitoengineering
Email: vsevolodpav@mail.ru
Russian Federation, Moscow, 119234
O. A. Averina
Lomonosov Moscow State University
Email: vsevolodpav@mail.ru
Russian Federation, Moscow, 119234
E. A. Kushnir
Institute of Mitoengineering
Email: vsevolodpav@mail.ru
Russian Federation, Moscow, 119234
N. V. Marmiy
Institute of Mitoengineering
Email: vsevolodpav@mail.ru
Russian Federation, Moscow, 119234
M. L. Lovat
Institute of Mitoengineering; Lomonosov Moscow State University
Email: vsevolodpav@mail.ru
Russian Federation, Moscow, 119234; Moscow, 119234