Amyloid properties of titin
- Авторлар: Yakupova E.1,2, Vikhlyantsev I.1,2, Lobanov M.3, Galzitskaya O.3, Bobylev A.1,2
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Мекемелер:
- Institute of Theoretical and Experimental Biophysics
- Pushchino State Institute of Natural Sciences
- Institute of Protein Research
- Шығарылым: Том 82, № 13 (2017)
- Беттер: 1675-1685
- Бөлім: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151554
- DOI: https://doi.org/10.1134/S0006297917130077
- ID: 151554
Дәйексөз келтіру
Аннотация
This review considers data on structural and functional features of titin, on the role of this protein in determination of mechanical properties of sarcomeres, and on specific features of regulation of the stiffness and elasticity of its molecules, amyloid aggregation of this protein in vitro, and possibilities of formation of intramolecular amyloid structure in vivo. Molecular mechanisms are described of protection of titin against aggregation in muscle cells. Based on the data analysis, it is supposed that titin and the formed by it elastic filaments have features of amyloid.
Негізгі сөздер
Авторлар туралы
E. Yakupova
Institute of Theoretical and Experimental Biophysics; Pushchino State Institute of Natural Sciences
Хат алмасуға жауапты Автор.
Email: yakupova.mira@mail.ru
Ресей, Pushchino, Moscow Region, 142290; Pushchino, Moscow Region, 142290
I. Vikhlyantsev
Institute of Theoretical and Experimental Biophysics; Pushchino State Institute of Natural Sciences
Email: yakupova.mira@mail.ru
Ресей, Pushchino, Moscow Region, 142290; Pushchino, Moscow Region, 142290
M. Lobanov
Institute of Protein Research
Email: yakupova.mira@mail.ru
Ресей, Pushchino, Moscow Region, 142290
O. Galzitskaya
Institute of Protein Research
Email: yakupova.mira@mail.ru
Ресей, Pushchino, Moscow Region, 142290
A. Bobylev
Institute of Theoretical and Experimental Biophysics; Pushchino State Institute of Natural Sciences
Email: yakupova.mira@mail.ru
Ресей, Pushchino, Moscow Region, 142290; Pushchino, Moscow Region, 142290
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