Amyloid properties of titin
- Authors: Yakupova E.I.1,2, Vikhlyantsev I.M.1,2, Lobanov M.Y.3, Galzitskaya O.V.3, Bobylev A.G.1,2
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Affiliations:
- Institute of Theoretical and Experimental Biophysics
- Pushchino State Institute of Natural Sciences
- Institute of Protein Research
- Issue: Vol 82, No 13 (2017)
- Pages: 1675-1685
- Section: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151554
- DOI: https://doi.org/10.1134/S0006297917130077
- ID: 151554
Cite item
Abstract
This review considers data on structural and functional features of titin, on the role of this protein in determination of mechanical properties of sarcomeres, and on specific features of regulation of the stiffness and elasticity of its molecules, amyloid aggregation of this protein in vitro, and possibilities of formation of intramolecular amyloid structure in vivo. Molecular mechanisms are described of protection of titin against aggregation in muscle cells. Based on the data analysis, it is supposed that titin and the formed by it elastic filaments have features of amyloid.
Keywords
About the authors
E. I. Yakupova
Institute of Theoretical and Experimental Biophysics; Pushchino State Institute of Natural Sciences
Author for correspondence.
Email: yakupova.mira@mail.ru
Russian Federation, Pushchino, Moscow Region, 142290; Pushchino, Moscow Region, 142290
I. M. Vikhlyantsev
Institute of Theoretical and Experimental Biophysics; Pushchino State Institute of Natural Sciences
Email: yakupova.mira@mail.ru
Russian Federation, Pushchino, Moscow Region, 142290; Pushchino, Moscow Region, 142290
M. Y. Lobanov
Institute of Protein Research
Email: yakupova.mira@mail.ru
Russian Federation, Pushchino, Moscow Region, 142290
O. V. Galzitskaya
Institute of Protein Research
Email: yakupova.mira@mail.ru
Russian Federation, Pushchino, Moscow Region, 142290
A. G. Bobylev
Institute of Theoretical and Experimental Biophysics; Pushchino State Institute of Natural Sciences
Email: yakupova.mira@mail.ru
Russian Federation, Pushchino, Moscow Region, 142290; Pushchino, Moscow Region, 142290
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