Amyloid properties of titin
- 作者: Yakupova E.1,2, Vikhlyantsev I.1,2, Lobanov M.3, Galzitskaya O.3, Bobylev A.1,2
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隶属关系:
- Institute of Theoretical and Experimental Biophysics
- Pushchino State Institute of Natural Sciences
- Institute of Protein Research
- 期: 卷 82, 编号 13 (2017)
- 页面: 1675-1685
- 栏目: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151554
- DOI: https://doi.org/10.1134/S0006297917130077
- ID: 151554
如何引用文章
详细
This review considers data on structural and functional features of titin, on the role of this protein in determination of mechanical properties of sarcomeres, and on specific features of regulation of the stiffness and elasticity of its molecules, amyloid aggregation of this protein in vitro, and possibilities of formation of intramolecular amyloid structure in vivo. Molecular mechanisms are described of protection of titin against aggregation in muscle cells. Based on the data analysis, it is supposed that titin and the formed by it elastic filaments have features of amyloid.
作者简介
E. Yakupova
Institute of Theoretical and Experimental Biophysics; Pushchino State Institute of Natural Sciences
编辑信件的主要联系方式.
Email: yakupova.mira@mail.ru
俄罗斯联邦, Pushchino, Moscow Region, 142290; Pushchino, Moscow Region, 142290
I. Vikhlyantsev
Institute of Theoretical and Experimental Biophysics; Pushchino State Institute of Natural Sciences
Email: yakupova.mira@mail.ru
俄罗斯联邦, Pushchino, Moscow Region, 142290; Pushchino, Moscow Region, 142290
M. Lobanov
Institute of Protein Research
Email: yakupova.mira@mail.ru
俄罗斯联邦, Pushchino, Moscow Region, 142290
O. Galzitskaya
Institute of Protein Research
Email: yakupova.mira@mail.ru
俄罗斯联邦, Pushchino, Moscow Region, 142290
A. Bobylev
Institute of Theoretical and Experimental Biophysics; Pushchino State Institute of Natural Sciences
Email: yakupova.mira@mail.ru
俄罗斯联邦, Pushchino, Moscow Region, 142290; Pushchino, Moscow Region, 142290
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