Email this article Advances in the Application of Modified Nucleotides in SELEX Technology
- Authors: Antipova O.M.1,2, Zavyalova E.G.1,2, Golovin A.V.2,3,4, Pavlova G.V.2,4,5,6, Kopylov A.M.1,2, Reshetnikov R.V.2,3,4,5
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Affiliations:
- Faculty of Chemistry
- Apto-Pharm Ltd.
- Faculty of Bioengineering and Bioinformatics
- Institute of Molecular Medicine
- Institute of Gene Biology
- Burdenko National Scientific and Practical Center for Neurosurgery
- Issue: Vol 83, No 10 (2018)
- Pages: 1161-1172
- Section: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151731
- DOI: https://doi.org/10.1134/S0006297918100024
- ID: 151731
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Abstract
Aptamers are widely used as molecular recognition elements for detecting and blocking functional biological molecules. Since the common “alphabet” of DNA and RNA consists of only four letters, the chemical diversity of aptamers is less than the diversity of protein recognition elements built of 20 amino acids. Chemical modification of nucleotides enlarges the potential of DNA/RNA aptamers. This review describes the latest achievements in a variety of approaches to aptamers selection with an extended genetic alphabet.
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About the authors
O. M. Antipova
Faculty of Chemistry; Apto-Pharm Ltd.
Author for correspondence.
Email: antipovachem@gmail.com
Russian Federation, Moscow, 119991; Moscow, 115564
E. G. Zavyalova
Faculty of Chemistry; Apto-Pharm Ltd.
Email: antipovachem@gmail.com
Russian Federation, Moscow, 119991; Moscow, 115564
A. V. Golovin
Apto-Pharm Ltd.; Faculty of Bioengineering and Bioinformatics; Institute of Molecular Medicine
Email: antipovachem@gmail.com
Russian Federation, Moscow, 115564; Moscow, 119234; Moscow, 119991
G. V. Pavlova
Apto-Pharm Ltd.; Institute of Molecular Medicine; Institute of Gene Biology; Burdenko National Scientific and Practical Center for Neurosurgery
Email: antipovachem@gmail.com
Russian Federation, Moscow, 115564; Moscow, 119991; Moscow, 119334; Moscow, 125047
A. M. Kopylov
Faculty of Chemistry; Apto-Pharm Ltd.
Email: antipovachem@gmail.com
Russian Federation, Moscow, 119991; Moscow, 115564
R. V. Reshetnikov
Apto-Pharm Ltd.; Faculty of Bioengineering and Bioinformatics; Institute of Molecular Medicine; Institute of Gene Biology
Email: antipovachem@gmail.com
Russian Federation, Moscow, 115564; Moscow, 119234; Moscow, 119991; Moscow, 119334
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