Отправить статью по E-mail Advances in the Application of Modified Nucleotides in SELEX Technology
- Авторы: Antipova O.1,2, Zavyalova E.1,2, Golovin A.2,3,4, Pavlova G.2,4,5,6, Kopylov A.1,2, Reshetnikov R.2,3,4,5
-
Учреждения:
- Faculty of Chemistry
- Apto-Pharm Ltd.
- Faculty of Bioengineering and Bioinformatics
- Institute of Molecular Medicine
- Institute of Gene Biology
- Burdenko National Scientific and Practical Center for Neurosurgery
- Выпуск: Том 83, № 10 (2018)
- Страницы: 1161-1172
- Раздел: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151731
- DOI: https://doi.org/10.1134/S0006297918100024
- ID: 151731
Цитировать
Открытый доступ
Доступ предоставлен
Только для подписчиков
Аннотация
Aptamers are widely used as molecular recognition elements for detecting and blocking functional biological molecules. Since the common “alphabet” of DNA and RNA consists of only four letters, the chemical diversity of aptamers is less than the diversity of protein recognition elements built of 20 amino acids. Chemical modification of nucleotides enlarges the potential of DNA/RNA aptamers. This review describes the latest achievements in a variety of approaches to aptamers selection with an extended genetic alphabet.
Ключевые слова
Об авторах
O. Antipova
Faculty of Chemistry; Apto-Pharm Ltd.
Автор, ответственный за переписку.
Email: antipovachem@gmail.com
Россия, Moscow, 119991; Moscow, 115564
E. Zavyalova
Faculty of Chemistry; Apto-Pharm Ltd.
Email: antipovachem@gmail.com
Россия, Moscow, 119991; Moscow, 115564
A. Golovin
Apto-Pharm Ltd.; Faculty of Bioengineering and Bioinformatics; Institute of Molecular Medicine
Email: antipovachem@gmail.com
Россия, Moscow, 115564; Moscow, 119234; Moscow, 119991
G. Pavlova
Apto-Pharm Ltd.; Institute of Molecular Medicine; Institute of Gene Biology; Burdenko National Scientific and Practical Center for Neurosurgery
Email: antipovachem@gmail.com
Россия, Moscow, 115564; Moscow, 119991; Moscow, 119334; Moscow, 125047
A. Kopylov
Faculty of Chemistry; Apto-Pharm Ltd.
Email: antipovachem@gmail.com
Россия, Moscow, 119991; Moscow, 115564
R. Reshetnikov
Apto-Pharm Ltd.; Faculty of Bioengineering and Bioinformatics; Institute of Molecular Medicine; Institute of Gene Biology
Email: antipovachem@gmail.com
Россия, Moscow, 115564; Moscow, 119234; Moscow, 119991; Moscow, 119334
