Advances in the Application of Modified Nucleotides in SELEX Technology

O. M. Antipova; E. G. Zavyalova; A. V. Golovin; G. V. Pavlova; A. M. Kopylov; R. V. Reshetnikov

doi:10.1134/S0006297918100024

Advances in the Application of Modified Nucleotides in SELEX Technology

作者: Antipova O.¹^,2, Zavyalova E.¹^,2, Golovin A.²^,3^,4, Pavlova G.²^,4^,5^,6, Kopylov A.¹^,2, Reshetnikov R.²^,3^,4^,5
隶属关系:
1. Faculty of Chemistry
2. Apto-Pharm Ltd.
3. Faculty of Bioengineering and Bioinformatics
4. Institute of Molecular Medicine
5. Institute of Gene Biology
6. Burdenko National Scientific and Practical Center for Neurosurgery
期: 卷 83, 编号 10 (2018)
页面: 1161-1172
栏目: Review
URL: https://journals.rcsi.science/0006-2979/article/view/151731
DOI: https://doi.org/10.1134/S0006297918100024
ID: 151731

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Aptamers are widely used as molecular recognition elements for detecting and blocking functional biological molecules. Since the common “alphabet” of DNA and RNA consists of only four letters, the chemical diversity of aptamers is less than the diversity of protein recognition elements built of 20 amino acids. Chemical modification of nucleotides enlarges the potential of DNA/RNA aptamers. This review describes the latest achievements in a variety of approaches to aptamers selection with an extended genetic alphabet.

关键词

aptamers, modified nucleotides, mod-SELEX

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Advances in the Application of Modified Nucleotides in SELEX Technology

全文:

详细

关键词

作者简介

O. Antipova

E. Zavyalova

A. Golovin

G. Pavlova

A. Kopylov

R. Reshetnikov